中文摘要：

目的探讨脑白质疏松及脑血管危险因素在记忆损害型帕金森病（PD）轻度认知功能障碍患者中的影响。方法根据神经心理学测验结果,将102例PD患者分为记忆受损组30例、非记忆受损组35例和认知正常组37例,运用Scheltens视觉评定量表评估脑白质疏松程度,比较3组侧脑室旁、脑深部白质、基底节区、小脑幕下区脑白质疏松程度差异;分析脑血管危险因素在3组中的影响。运用多元线性回归分析脑白质疏松和脑血管危险因素等对记忆损害型PD轻度认知功能障碍患者的影响。结果记忆受损组额叶高信号、侧脑室旁白质高信号较认知正常组和非记忆受损组明显增高（P〈0.05）。与认知正常组和非记忆受损组比较,记忆受损组TC明显升高[（5.87±0.81）mmol/L vs（3.86±1.10）mmol/L,（4.82±1.08）mmol/L],HDL-C明显降低[（1.17±0.24）mmol/L vs（1.26±0.53）mmol/L,（1.27±0.36）mmol/L,P〈0.05]。多元线性回归分析显示,侧脑室旁脑白质高信号、TC与视觉再生呈负相关（β=-0.341,P=0.000;β=-0.212,P=0.030）,教育程度与视觉再生呈正相关（β=0.201,P=0.038）。结论侧脑室旁脑白质疏松、高TC和高密度脂蛋白降低可能会导致PD-MCI患者的记忆受损。

英文摘要：

Objective To study the leukoaraios and cerebrovascular risk factors amnestic PD patients with mild cognitive impairment（MCI）.Methods One hundred and two PD patients were divided into amnestic group（n=37）,non-amnestic group（n=30）and normal cognition group（n=35）according to their neuropsychological assessment.Leukoaraios was scored according to the Scheltens Quantitative Visual Scale.The severity of leukoaraios was compared according to the signals from periventricular,deep white matter,basal ganglia and tentorium of cerebellum.The risk factors for cerebrovascular disease in amnestic PD patients were analyzed by multivariate linear regression analysis.Results The signals from periventricular white matter were significantly stronger in amnestic group than in other groups（P〈0.05）.The serum level of TC was significantly higher while that of HDL-C was significantly lower in amnestic group than in other groups（P〈0.05）.Multivariate regression analysis showed that periventricular hyperintensities and serum TC level were negatively related with regenerative vision（β=0.201,P=0.038;β=-0.341,P=0.000）while education level was positively related with regenerative vision（β=-0.212,P=0.030）.Conclusion Periventricular hyperintensities,increased TC level and decreseased HDL-C level are the risk factors for memory impairement in PD patients with MCI.