目的:观察复方丹参滴丸对经皮冠状动脉介入治疗患者胱抑素C及同型半胱氨酸的影响。方法:选取经皮冠状动脉介入治疗的急性冠状动脉综合征患者168例,随机分为观察组和对照组各84例。两组患者均给予常规对症治疗。观察组患者入院当天开始服用复方丹参滴丸治疗。结果:经皮冠状动脉介入治疗后,两组患者肌酐、高敏C反应蛋白、胱抑素C及同型半胱氨酸较术前增高(P〈0.05);术后24h、48h,观察组肌酐、高敏C反应蛋白、胱抑素C及同型半胱氨酸水平均明显低于对照组(P〈0.05)。结论:复方丹参滴丸对PCI术后肾功能有一定的保护功效,对造影剂肾病的发生有防治作用。
Objective: To observe the influence of Compound Danshen Dripping Pills on cystatin C( Cys C) and homocysteine( HCY) of patients with percutaneous coronary intervention( PCI). Methods: 168 cases with acute coronary syndrome received PCI were randomized into observation group and control group,with 84 cases in each group. Both groups were given conventional symptomatic treatment and observation group were given Compound Danshen Dripping Pills from the very day admitted into the hospital. Results: After percutaneous coronary intervention,the levels of creatinine,high-sensitivity C-reactive protein,Cys C and HCY increased in both groups when compared with these before the treatment( P 〈0. 05). After 24 h and 48 h of the operation,the levels of creatinine,high-sensitivity C-reactive protein,Cys C and HCY in observation group were significantly lower than these in control group( P 〈0. 05). Conclusion: Compound Danshen Dripping Pills has certain protection for the kidney function and certain preventive and therapeutic effect on the radiographic contrast nephropathy of patients after PCI.