中文摘要：

我们设计了一系列新型S-DABOs类目标化合物7a{通过简单有效的方法合成了该系列化合物，并进行了逆转录酶活性检测，发现该类化合物具有较好的生物活性，其中化合物7d的IC50值达到了3．64μmol／L，是Nevir印ine的IC50值的1／2。

英文摘要：

A series of novel dihydro-alkylthio-benzyl-oxopyrimidines （S-DABOs） 7a-f have been designed and synthesized with an efficient method. Biological evaluation of their HIV-1 reverse transcriptase inhibitory activities was performed using Nevirapine （NVP） as a reference compound. Among the series, compound 7d shows the highest reverse transcriptase inhibitory activity, which is better than Nevirapine.