中文摘要：

目的：探讨脑梗死后弥散加权成像（ DWI ）及表面弥散系数（ ADC ）在猴脑梗死模型中的应用价值及变化规律。方法选择8只广西猕猴为实验动物，经股动脉穿刺插管至颈总动脉，引入微导管超选至大脑中动脉后注入适量自体血栓，分别于栓塞后1、2、24 h及7、14、21、28 d行磁共振检查并测量ADC值。结果栓塞后1 h 6只实验猴DWI显示高信号，术后2 h 8只实验猴DWI均显示高信号，而T1 WI及T2 WI均无显示；24 h DWI呈明显高信号，T2 WI呈高信号；7 d时DWI呈高信号，14 d时DWI呈稍高信号，21 d时 DWI呈等或低信号，28 d时DWI呈低信号，而T2 WI均呈高信号。24 h内ADC值逐渐降低，7 d时升高至接近正常，14、21、28 d时高于正常值并呈逐步升高。结论 DWI比常规T2WI更早发现脑梗死信号；在脑梗死急性期，DWI呈高信号而ADC下降，在亚急性期及慢性期ADC逐渐上升，DWI信号逐渐降低，但两者并不同步。

英文摘要：

Objective To discuss the values of diffusion-weighted imaging （ DWI） and apparent diffusion co-efficient （ ADC） in the cerebral infarction model of monkey ,and to analyze their change rules .Methods A total of 8 healthy adult monkeys （ Macaca mulatta ） were used as the experimental animals .The model was established by injec-ting autoblood clots into middle cerebral artery through the inserted micro-catheter to occlude the artery .MRI was per-formed in the first hour,second hour,24th hour,7th day,14th day,21th day and 28th day after embolization,and the values of ADC were measured .Results MRI performed in the first hour showed the high signals on DWI in 6 mon-keys,and showed the high signals on DWI in the second hour in 8 monkeys.And no abnormal findings were observed on T1WI and T2WI.DWI showed the significantly higher signals and T 2WI showed the high signals in the 24th hour. DWI showed the high signals on the 7th day and the slightly higher signals on the 14th day,but it showed the equal or low signals on the 21th day and the low signals on the 28th day.T2WI showed the high signals in all time .ADC values decreased within 24 hours,which increased to be almost normal on the 7th day and gradually increased to be higher than the normal on the 14th day,21th day and 28th day.Conclusion DWI shows the cerebral infarction earlier com-pared with routine T2WI.In the acute cerebral infarction stage ,DWI shows the high signals while ADC decreases .In the subacute and chronic stages ,ADC gradually increases while DWI signals gradually decreases ,but both are not syn-chronous.