越来越多的研究表明,从雌性哺乳动物和人卵巢表面上皮细胞中能够分离出少量端粒酶活性高、表达干性标志且能被诱导发育成为卵母细胞样的卵巢干细胞,即生殖干细胞(GSCs)。体内移植后,可使不孕小鼠产生排卵,生育后代。GSCs可能在维持出生后卵泡的再生与修复中发挥重要作用。然而,GSCs的研究还存在一些缺陷和存在性的直接证据。本文主要对卵巢GSCs的研究进展和潜在的应用前景进行了综述。
Studies have shown that a bit of ovary stem ceils were isolated from female mammal and human epithelial cells of the ovary surface. These ovary stem cells have high telomerase activity, and express some of sternness markers. The ovary stem cells can be induced to develop into oocyte-like in vitro. After the oocyte-like cells were transplanted, infertile mice could cause ovulate, then producd offspring. Researchers believe that the kind of ovary stem cells precisely is germline stem cells (GSCs). They may play an important role in maintain of follicle's regeneration and repairmen after birth. Nevertheless, there are still have some deficiencies and lack of more direct evidence in vivo about the existence of GSCs. This article review some of research progress and application prospect on ovary GSCs.