中文摘要：

目的：系统评价香菇多糖联合化疗治疗晚期胃癌的疗效及安全性。方法：通过计算机检索中国期刊全文数据库、维普数据库、万方数据库、CBM、Pub Med、EMBASE（via Ovid SP）、Medline（via Ovid SP）、Cochrane central数据库中从创建以来至2015年10月30日关于香菇多糖联合化疗治疗晚期胃癌的相关文献,由两名研究人员独立交叉筛选相关随机对照试验（randomized controlled trails,RCT）,并进行质量评估和数据提取,采用Revman 5.3进行数据分析。结果：纳入14个RCT,共计1161例研究对象,其中香菇多糖注射液联合化疗组603例,单纯化疗组558例。Meta分析结果显示：香菇多糖联合化疗组与单纯化疗组相比,其肿瘤的近期有效率、生活质量改善率的差异均有统计学意义[近期有效率：[RR=1.57,95%CI（1.39,1.77）,P〈0.00001,生活质量改善率：RR=1.80,95%CI（1.23,2.65）,P=0.003],而且香菇多糖联合化疗组在Ⅱ°-Ⅳ°。白细胞抑制发生率[RR=0.56,95%CI（0.41,0.77）,P=0.0004]、Ⅱ°-Ⅳ°。胃肠道反应发生率[RR=0.53,95%CI（0.40,0.70）,P〈0.0001]以及神经毒性发生率[RR=0.56,95%CI（0.40,0.79）,P=0.0008]均低于对照组。结论：基于目前的临床研究,香菇多糖联合化疗治疗中晚期胃癌可提高肿瘤的近期有效率,改善患者生活质量以及降低化疗的毒副作用。

英文摘要：

Objective ： To evaluate the efficacy and safety of lentinan combined with chemotherapy for advanced gastric carcino- ma. Methods ： CNKI, VIP, Wanfang database, CBM, PubMed, EMBASE（ via ovidSP ） , Medline（ via ovidSP ） , Cochrane central were searched from their inception to October 30th 2015 to collect the literature about lentinan combined with chemotherapy for ad- vanced gastric cancer. Two reviewers independently searched the databases, collected the randomized controlled trials, performed the data extraction and appraised the publications. The Reviewer Manager 5.3 software was employed for data analysis. Results ： Fourteen trials were included for analysis, a sum of 1161 patients were enrolled in these studies. Compared to using chemotherapy alone,lentinan combined with chemotherapy significantly increased the immediate tumor response, improved Karnofsky perform- ance scores （ immediate tumor response ： RR = 1.57,95 % CI （ 1.39,1.77 ） , P 〈 0.00001, quality of life improvement rate ： RR = 1.80,95% CI （1.23,2. 65 ）, P = 0. 003 ] and lentinan combined with chemotherapy group in II~ -IV~leukocyte inhibition rate [ RR = 0. 56,95 % CI （0. 41,0. 77 ）, P = 0. 0004 ], II° - IV° the incidence rate of gastrointestinal reactions [ RR = 0. 53,95 % CI （0. 40,0. 70）, P = 0. 0001 ] and nenrotoxicity incidence rate [ RR = 0. 56,95 % CI （0. 40, 0. 79 ）, P = 0. 0008 ] were all lower than those of the control group. Conclusion ： Lentinan combined with chemotherapy can improve the efficacy for advanced gastric carcinoma patients and reduce side effect.