中文摘要：

目的：探讨皮下注射八肽胆囊收缩素（CCK-8S）对砷中毒大鼠热刺激缩足反射潜伏期（paw withdraw ther-mal latency，PWTL）的影响。方法：wistar雌鼠32只，体重180-220g，出生8-10周，随机分为四组，A组（n=8）：尾静脉注射生理盐水组;B组（n=8）：尾静脉注射亚砷酸钠（NaAsO2）组;C组（n=8）：尾静脉注射NaAsO2＋皮下注射CCK-8S组;D组（n=8）：尾静脉注射NaAsO2＋皮下注射生理盐水组。在注射前、注射后2、4、6、8、10、12、14、16天分别进行热板实验，记录PWTL。在PWTL达到最小值时，C组皮下注射CCK-8S后，D组皮下注射生理盐水，分别在注射前及注射后15、30、45、60、759、0分钟进行热板实验。结果：在注射NaAsO2后第8天，B组的PWTL与A组及注射NaAsO2前相比较差异均具有显著性（P〈0.01），砷中毒模型制备成功。在第8天，发现C组PWTL在15-60分钟时与注射CCK-8S前及D组比较均显著的延长（P〈0.05）。结论：CCK-8S能显著降低砷中毒大鼠的热痛觉过敏，对砷中毒大鼠有镇痛作用。

英文摘要：

Objective： To investigate the effect of cholecystokinin octapeptide on PWTL of arsenic- poisoning rat. Methods：Thirty two female Wistar rats （8 - 10 weeks）weighing 180 - 220 g were randomly divided into four equal groups, each group ＇has 8 animals： group A inject 0. 9 % sodium chloride at 1ml/100g, group B received NaAsO2 injection, group C inject NaAsO2 first, then CCK- 8S at 0.05mg/kg via subcutaneous,group D received NaAsO2 first, then 0. 9 % sodium chloride via subcutaneous. The NaAsO2 injection and 0. 9 % sodium chloride of A were injected via caudal vein. The PWTL was measured by a hot plate test （55℃）before NaAsO2 injection in 2,4,6 ,8 , 10 , 12 , 14,16 days . While the PWTL achieved minimum value, group C inject CCK - 8S and group D inject 0. 9 % sodium chloride via subcutaneous. The PWTL of group C and group D was measured bcfore and ＇after injection in 15,30,45,60,75,90 minutes. Results：Before experiment there was no significant difference in PWTL between group A and group B（P 〉 0.05）, after 8 days there is significant difference in PWTL between group A and group B（P〈 0.01 ）, these data have show that subacute arsenic-poisoning rat model was successfully induced. After CCK- 8S injection there was significant prolong in PWTL in group C between 15 min and 60 min compared to before injection and group D （ P 〈 0.05）. Conclusion： This study shows that CCK - 8S significant reduces the thermal hyperalgesia of arsenic-poisoning rat CCK - 8S have analgesic effect to arsenic-poisoning rat.