电压门控性钙通道是一类广泛分布在中枢神经系统和外周神经系统中功能结构不同的离子通道家族。这类通道参与痛觉的调制,并且在神经元递质的释放、动作电位的激发和神经元的兴奋性改变中发挥着重要的作用,本文就各类钙通道在痛觉机制中的作用做一综述。
The voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of ion channels found throughout the central nervous system (CNS) and periphery. Neuronal functions include the control of neurotransmitter release, action-potential firing and neuronal excitability in important pain pathways. In this review we will give an overview of the data that has been generated in support of these channels performing a key role in the pain pathway.