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遗传和环境因素对我国成年男性双生子吸烟行为影响的分析
  • ISSN号:0254-6450
  • 期刊名称:《中华流行病学杂志》
  • 时间:0
  • 分类:R163[医药卫生—公共卫生与预防医学]
  • 作者机构:[1]北京大学公共卫生学院,100191, [2]青岛市疾病预防控制中心,266033, [3]浙江省疾病预防控制中心,杭州310051, [4]北京市疾病预防控制中心,100013, [5]上海市疾病预防控制中心,200336, [6]江苏省疾病预防控制中心,南京210009, [7]四川省疾病预防控制中心,成都610041, [8]天津市疾病预防控制中心,300011, [9]青海省疾病预防控制中心,西宁810007, [10]哈尔滨医科大学公共卫生学院,150001
  • 相关基金:公益性行业科研专项(201502006,201002007);教育部科学技术研究重大项目(310006)
中文摘要:

目的分析遗传和环境因素分别对成年男性吸烟、戒烟和开始吸烟年龄〈20岁3个吸烟行为相关维度的影响。方法利用电子问卷面对面调查法获得中国双生子登记系统中9省/市的6458对25岁及以上成年男性双生子的吸烟行为相关信息,通过拟合结构方程模型,计算遗传和环境对吸烟相关行为的影响。结果成年男性双生子吸烟、戒烟以及开始吸烟年龄〈20岁3个维度的最佳模型均为ACE模型,其遗传度分别为0.26(0.19—0.34)、0.27(0.19—0.37)和0.05(0.00~0.14);调整地区和年龄因素后,3个维度的遗传度分别为0.26(0.19—0.34)、0.31(0.00~0.74)和0.05(0.00.0.14)。结论吸烟相关行为的3个维度均受到遗传因素的影响,但环境因素对这类行为的影响更大,其中戒烟行为的遗传度较高,受到环境影响较小;开始吸烟年龄则受环境影响最大。

英文摘要:

Objective To analyze the influences of genetic and environmental factors on smoking behavior, smoking cessation and onset age of smoking less than 20 years in male twin adults. Methods A face-to-face questionnaire was conducted to collect data from 6 458 pair male twins aged ≥25 years registered in 9 provinces (municipality) in China. The heritability of three smoking related behaviors were calculated by using structural equation models. Results The ACE models were the best models of the three dimensions of smoking, i.e. smoking behavior, smoking cessation and onset age of smoking less than 20 years for male twins, and the corresponding heritability of these behaviors were 0.26 (0.19-0.34), 0.27 (0.19-0.37) and 0.05 (0.00-0.14), respectively. When adjusted for area and age, the heritability of these three behaviors were 0.26 (0.19-0.34), 0.31 (0.00-0.74) and 0.05 (0.00-0.14), respectively. Conclusions All the three smoking related behaviors were affected by genetic factors, but environment factors had more effect on them. For smoking cessation, the heritability was highest, but the influence of environmental factors was lowest. Meanwhile, for onset age of smoking, the influence of environmental factors was highest.

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期刊信息
  • 《中华流行病学杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京昌平区昌百路155号传染病所B115
  • 邮编:102206
  • 邮箱:lxbonly@public3.bta.net.cn
  • 电话:010-58900730
  • 国际标准刊号:ISSN:0254-6450
  • 国内统一刊号:ISSN:11-2338/R
  • 邮发代号:2-73
  • 获奖情况:
  • 1999年预防医学会优秀期刊一等奖,1996年中华医学会中华预防医学会优秀期刊奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),美国生物医学检索系统,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:62798