中文摘要：

肿瘤细胞在氧含量充足的情况下仍倾向于糖酵解,被称之为Warburg效应,这是肿瘤细胞的重要特征之一,现在认为它是癌基因和抑癌基因共同作用的结果。目前研究表明microRNAs能够在转录后水平参与相关基因的表达,通过多种途径调节肿瘤细胞的糖代谢方式。其中丙酮酸激酶参与糖酵解的最后一个阶段,不同亚型的表达水平差异能调控糖代谢方式。本文着重探讨microRNAs调控丙酮酸激酶的作用机制,及其对肿瘤细胞产生的影响,为临床治疗提供理论基础。

英文摘要：

Warburg effect means that the tumor cells tend to glycolysis even under condition of the content oxygen, which is one of the most important characters of tumor cells. In addition , it is result of interaction of oncogene and tumor suppressor genes. MicroRNAs （miRNA ） can adjust the glycolysis of tumor cells ,by involvin g in the expression of related genes in the transcription level. Pyruvate kinase （P K ） participates in the last stage of gly colysis, the differ-ence of PK subtypes expression levels can regulate glucose metabolism. The review focuses on the mechanism of pyru-vate kinase regulation mediating by MiRNAs ,and its effects on tumor cells ,which may provide theoretical basis for clinical treatment.