中文摘要：

目的：分析宫颈脉管内癌栓浸润（lymph-vascular space invasion,LVSI）与宫颈癌其他临床病理因素的关系,为指导宫颈癌治疗提供依据。方法：回顾性分析2003年4月—2013年5月上海市第一妇婴保健院收治的462例宫颈癌患者的临床及病理资料,其中LVSI阳性者185例（40%）,阴性者277例（60%）,对LVSI与肿瘤分期、淋巴结转移及其他临床、病理因素的关系进行相关性分析。结果：单因素分析显示宫颈癌患者LVSI的发生与肿瘤分期、肿瘤大小、浸润深度、淋巴结转移、是否术前经过新辅助治疗有关,而与采用何种新辅助治疗方法无关。LVSI与宫颈癌的其他5项高危因素,即组织病理学类型、间质浸润深度、肿瘤体积、宫旁浸润、淋巴结转移有关;且合并的高危因素越多,LVSI的发生率越高。结论：LVSI与其他病理高危因素密切相关,可能更早地提示淋巴结转移等其他高危因素的潜在风险,对指导宫颈癌的治疗意义重大。

英文摘要：

Objective：To analyze the relationship between the lymph-vascular space invasion（LVSI） in cervical cancer and other histo-pathologic parameters, in order to provide some guidance for choosing treatment. Methods：Clinical and pathological data of 462 cervical cancer patients were analyzed retrospectively from April 2003 to May 2013 in Shanghai First Maternity and Infant Hospital of which LVSI positive（40%） and 277 cases negative（60%）. An analysis was done in terms of the relationship between LVSI and stage and grade of the disease, as well as lymph-node metastasis and other histo-pathologic parameters. Results：In single variable analysis, the presence of LVSI appeared to have obvious relationship with FIGO staging,tumor size, depth of tumor invasion, lymph-nodes metastasis and whether neoadjuvant therapy, but there was no statistic significance with whatever neoadjuvant therapy use. In multivariable analysis, LVSI appeared to have significant association with other histo-pathologic parameters such as histopathological types, stromal invasive depth, tumor size, parametrial infiltration and lymph-nodes metastasis. And the incidence of LVSI was elevated with the increasing number of parameters.Conclusions：LVSI closely related with other pathological risk factors. LVSI can hint the potent danger of lymph-nodes metastasis, and can provide guidance for clinically treatment.