中文摘要：

目的：探讨嗜酸粒细胞趋化因子（Eotaxin）-3在慢性鼻-鼻窦炎、鼻息肉组织中的表达及临床意义。方法：以15例鼻窦炎患者筛窦炎性黏膜（鼻窦炎组）,25例鼻息肉患者中鼻道息肉（鼻息肉组）以及7例鼻腔鼻窦非炎性疾病之筛窦或钩突黏膜组织（对照组）作为研究对象,采用免疫组织化学SABC检测分析方法检测组织中的Eotaxin-3表达情况,并分析其表达量与外周血嗜酸粒细胞计数之间的相关性。结果：Eotaxin-3在鼻窦炎性黏膜和息肉组织内均呈阳性表达,表达量均高于对照组,差异均有统计学意义（P〈0.05）,而且鼻息肉组其表达量高于鼻窦炎组,差异有统计学意义（P〈0.05）。鼻息肉组与鼻窦炎组中Eotaxin-3的表达量均与外周血嗜酸粒细胞计数呈显著正相关（P〈0.05）。结论：Eotaxin-3可能参与了慢性鼻-鼻窦炎和鼻息肉的发病,对此进行深入研究有助于进一步了解其病理生理学机制。

英文摘要：

Objective：To investigate the expression and clinical significance of Eotaxin-3 in chronic rhinosinusitis with and without nasal polyps.Method：The ethmoid inflammation mucosa of 15 cases diagnosed as chronic rhinosinusitis（sinusitis group）,the nasal polyps in the middle meatus of 25 cases diagnosed as nasal polyps（nasal polyp group）and the ethmoid or uncinate process mucosa of 7 cases diagnosed as sinonasal non-inflammatory diseases（control group）were collected as the research object.Eotaxin-3 expression was detected in the tissues by immunohistochemical SABC assay and the correlation between Eotaxin-3 and blood eosinophil counts was analyzed.Result：Eotaxin-3 were detected both in sinusitis group and nasal polyp group,and the expression level in sinusitis group and nasal polyp group were higher than that in control group.The difference was statistically significant（P〈0.05）.The Eotaxin-3 expression in nasal polyps group was higher than that in sinusitis group,and the difference was statistically significant（P〈0.05）.The expression of Eotaxin-3 in nasal polyps group and sinusitis group were both significantly positively correlated with the eosinophil counts in the blood（P〈0.05）.Conclusion：Eotaxin-3 may be involved in the pathogenesis of chronic rhinosinusitis with and without nasal polyps,and further research will help us to understand the pathophysiology of chronic rhinosinusitis with and without nasal polyps.