中文摘要：

铅暴露的情况存在于许多企业中,如电子厂、蓄电池厂、冶炼厂、电子垃圾回收厂等。在相同的铅暴露水平上,不同的人群有不同的生物学效应。这在很大程度上取决于人群的遗传易感性。通过铅暴露场所的流行病学调查,运用血尿铅检测、外周血彗星实验、微核实验等方法可以研究铅暴露人群的健康效应与遗传易感性之间的关系,该文介绍了铅遗传易感性基因[δ-氨基-γ-酮戊酸脱水酶（δ-ALAD）基因、维生素D受体基因（VDR）、血色素沉着病基因（HFE）等]与铅暴露的关系,以及铅暴露对发育相关基因（Cbfα1、Brn-3α、Oct-2等）的影响,提出应对铅暴露人群加强易感基因的筛查,保护易感人群健康。

英文摘要：

The cases of lead exposure are present in many industries, such as electronics factory, battery plants, smelters, and other e-waste recycling plant. At the same level of lead exposure, different people showed various biological effects after exposure. This difference is mainly caused by genetic susceptibility depending on the crowd. The relationship between lead exposure effects and genetic susceptibility can be understood through epidemiological studies, blood and urinary lead monitoring, peripheral blood comet assay, micronucleus test. This paper introduced the relationship between lead exposure and the genetic susceptibility genes （ALAD,VDR, HFE, etc.） expression, and the influence of lead exposure on developmental- related gene （Cbfal, Brn-3a, Oct-2, etc.）, to propose deal with strengthening gene screening of lead exposure susceptible CoDulation and protecting, their health.