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中文摘要：
癫痫是神经系统疾病中较为常见的疾病之一，由大量神经元反复发作的异常放电而引起的中枢神经系统短暂性功能失常为特征。癫痫的发病机制非常复杂，包括Ca^2＋内流引发的细胞毒性；苔藓纤维芽生假说；谷氨酸和γ-氨基丁酸及其受体结构和功能异常；氧化应激损伤等。其中，过度的钙内流在癫痫发作中起着重要的作用，而过多的钙内流主要是通过改变钙离子通道引起的，现已有大量研究表明钙离子通道参与了癫痫发病过程。
英文摘要：
The Cav 2. 3 encoded Ca2 ＋ channel is one of the least well - known voltage - gated calcium channels in terms of physiology, pharmacology and clinical relevance. Epilepsy is a family of neurological disorders that are common and harmful to human health. More and more studies such as gene knock -out experiment have demonstrated that the channel is related to epileptic seizure, including participating to plateau potential generation, regulating intracellular Ca^2＋ concentration, Cav 2. 3 splice variant, interacting with some muteins. In addition, some antiepileptic drugs inhibit the epileptiform discharges by targeting Cav 2. 3 voltage - gated calcium channel.
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