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中文摘要：
微流控细胞分离芯片中流场的分布对混合细胞的有效分离有非常重要的意义，是细胞分离芯片结构设计的一个重要因素。本文设计了一种细胞分离芯片，用于将细胞融合实验后的融合细胞从大量未融合细胞中自动分离出来。为进一步研究芯片中流场分布与芯片结构的关系，利用CFD分析软件Fluent对微流控细胞分离芯片中的流场进行仿真分析，得到其流速分布。针对微通道中的流动情况实验分析表明，实验与仿真结果相比误差在10％以内，证明了CFD软件仿真在细胞分离芯片结构的设计中的指导作用。通过对仿真结果的对比分析，选择了一个优化的芯片结构模型并制作了Y型通道的微流控分离芯片。
英文摘要：
Flow profile in microfluidic cell sorting chip is of great significance for effectual cell separation and it is also an important factor in chip design. In this paper, a novel cell sorting chip is designed for separating fused cells from unfused cells. In order to research the interaction between flow field profile and chip structure, CFD software （Fluent） was used to simulate the flow field in microfluidic cell sorting chip and achieve the velocity profile. According to the simulation and on-chip experiment, the difference between experimental and simulation results is less than 10% , which validates that CFD simulation could be used as an important guidance in chip design. Comparing with the simulation results of different models, Y type mierochannel structure is chosen for the following cell sorting research.
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