中文摘要：

系统评价了液相色谱-电喷雾串联质谱测定猪肌肉与肝脏组织中氯丙那林、西马特罗、特布他林、妥布特罗、沙丁胺醇、克伦特罗、喷布特罗、莱克多巴胺及非诺特罗9种β-兴奋剂残留的基质效应及其影响因素。以甲醇、乙腈及乙酸乙酯提取猪肝脏,9种分析物的基质效应分别为13.4%～47.0%、19.9%～63.2%及33.5%～69.6%。多因素方差分析表明,提取溶剂及猪组织来源是引起基质效应的主要因素;固相萃取小柱净化后,分析物浓度对肌肉与肝脏中β-兴奋剂（除莱克多巴胺）的基质效应影响显著;3种SPE小柱对猪组织中喷布特罗的基质效应影响差异显著。

英文摘要：

Matrix effects （MEs） and its influencing factors on the determination of 9 β-agonists （ clorprenaline, cimaterol, terbutaline, tulobuterol, salbutamol, elenbuterol, penbutolol, ractopamine and fenoterol） residues in pig muscle and liver determined by using liquid chromatography-electrospray ionization tandem mass spectrometry were systematically evaluated. Matrix effects of 9 analytes in pig liver matrix solution extracted with methanol, aeetonitrile and ethyl acetate were 13.4%-47. 0%, 19. 9%-63. 2% and 33. 5%-69. 6%, respectively. The results of multivariate analysis of variance （MANOVA） showed that extraction solvents and pig tissues sources were main factors of matrix effect. After pig muscle and liver extracts were purified with different solid phase extraction cartridges, the concentration of analytes had a significant effect on MEs of all other analytes except ractopamine. There were significant differences in matrix effects of penbutolol among the three SPE cartridges.