中文摘要：

为了研究山茱萸与熟地两种药物不同比例配伍时山茱萸中主要组分的变化规律，利用高效液相色谱（HPLC）法和电喷雾质谱（ESIMS）法比较山茱萸和熟地药材单煎液、合煎液和单煎合并液中山茱萸主要组分的含量变化和各溶液的谱学行为。在一定质量比例内（m（山茱萸）：m（熟地）≤4：8），山茱萸与熟地共煎有相互协同溶出的效应。合煎液中山茱萸莫诺苷、马钱苷和没食子酸组分的百分含量随熟地配伍比例的增加均呈现线性变化规律。不同的配伍方式（合煎与单煎合并）会产生不同的新物质。结果表明，熟地组分的存在对山茱萸组分的溶出有较大影响，但该影响不受温度的限制。

英文摘要：

To study the contents variation of main components in Fructus Corni （FC） after combination with Radiac Rehmanniae Prepatrata （RRP）. The reciprocity of FC with RRP were investigated by means of high performance liquid chromatography （HPLC） and electrospray ionization mass spectrometry （ESI-MS） technique in the negative ion mode. FC with RRP was decocted separately, and then the separate aqueous extracts were combined partly. Different proportions of FC with RRP were decocted together. The contents of Morroniside, Loganin and Gallic acid in these samples were analyzed, synchronously, mass action of these samples were examined. FC with RRP promoted each other in dissolving percents in certain suitable quality proportion （FC ： RRP 4 ： 8）. Together-decocted and single-decocted merger can produce different new materials. The existence of RRP has grea influence on the dissolution of components in FC which would not restricted by temperature. It provides a certain science basis for the reasonable Chinese herbal medicine.