中文摘要：

目的探讨乙型肝炎病毒（HBV）感染患儿造血干细胞移植前后肝功能变化，为临床治疗提供参考依据。方法回顾性分析医院2006年8月一2011年8月58例行造血干细胞移植的HBV感染患儿临床资料，HBsAg阳性者15例为HBsAg阳性组，HBsAb阳性者43例为HBsAb阳性组；随机抽取同期行造血干细胞移植的无HBV感染患儿30例为对照组，分析移植前后肝功能变化，数据采用SPSS13．0进行分析。结果在移植后1周时各组患儿均出现ALT、AST、TBIL、IBIL升高，TP降低；在移植后6个月时，ALT及AST异常率HBsAg阳性组为73．33％、60．00％，HBsAb阳性组为39．53％、30．23％，对照组为30．00％、13．33％；HBsAg阳性组与HB-sAb阳性组及对照组比较，差异均有统计学意义（P〈0．05）；移植后6个月时HBsAg阳性组存活的11例患儿均转为HBsAg携带者，HBsAb阳性组存活的34例患儿中26例乙型肝炎指标全部转阴。结论HBsAg阳性患儿在行造血于细胞移植时肝功能受损，较HBsAb阳性患儿及未合并有HBV感染患儿更为严重，需要加强保肝治疗。

英文摘要：

OBJECTIVE To investigate changes of liver function before and after hematopoietic stem cell transplantation in children with hepatitis B virus （HBV） infection so as to provide reference for clinical treatment. METHODS The clinical data of 58 HBV infected children undergoing hematopoietic stem cell transplantation during Aug. 2006 to Aug. 2011 were retrospectively analyzed, 15 children with positive HBsAg were taken as the HBsAg positive group, 43 positive with HBsAb positive as the HBsAb positive group. Meanwhile 30 children who underwent hematopoietic stem cell transplantation and did not have HBV infection during the same period were randomly selected as the control group. The changes of liver function before and after transplantation were analyzed, and the statistical analysis of the data was performed with the use of spss 13.0 software. RESULTS At weekl after transplantation, both groups of patients had elevated ALT, AST, TBIL, and IBIL and decreased TP. After the transplantation for 6 months, the abnormal rate of ALT and AST was 73.33%, 73.33% in the HBsAg positive group, 39.53%, 39.53% in the HBsAb positive group, and 30. 00%, 13.33% in the control group. There was statistically significant difference between the HBsAg positive, the HBsAb positive and the control groups （P〈0.05）. After transplantation for 6 months, 11 survival children in the HBsAg positive group were converted to HBsAg carriers, 26 in 34 survival children in the HBsAb positive group were converted to be negative for all the hepatitis B indicators. CONCLUSION Damage of liver function in the HBsAg positive children during hematopoietic stem cell transplantation is more severe than that in HBsAb positive children without HBV infection, therefore, liver-protecting treatment needs to be strengthened.