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GIT1通过BMP-2/p-Smad1/5/8信号通路调节骨折愈合
  • ISSN号:1007-4368
  • 期刊名称:《南京医科大学学报:自然科学版》
  • 时间:0
  • 分类:R681[医药卫生—骨科学;医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029,China, [2]Department of Orthopaedics, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing,Jiangsu 210029, China
  • 相关基金:Acknowledgments This work was supported by National Natural and Science Foundation (81271988), Jiangsu Natural and Science Foundation (BK2012876).
中文摘要:

This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture(OVCF),who received balloon kyphoplasty.Patients were divided into four groups:Group 1 had no superior endplate fracture,Group 2 had fractures on the anterior portion of the superior endplate,Group 3 had fractures on the posterior portion of the superior endplate,and Group 4 had complete superior endplate fractures.Anterior and middle vertebral body height,vertebral compression ratio,vertebral height loss rate,and kyphosis Cobb angle of each patient were measured and visual analogue scale(VAS) and Oswestry disability index(ODI) scores were recorded.The anterior vertebral height and kyphosis deformity of all groups significantly improved after the surgery,whereas substantial anterior vertebral height loss and increased Cobb angle were observed in all patients at the last follow-up.Although the vertebral height loss rate and the Cobb angle in Group 2,3 and 4 were larger compared with Group 1 at the last follow-up,only the vertebral height loss rate in Group 4 and the increase in the Cobb angle in Group 2 and 4 were statistically different from those in Group 1.The VAS and ODI scores in all groups measured after the surgery and at the last follow-up were significantly lower compared with preoperative scores,but there was no significant difference among these groups.Balloon kyphoplasty significantly improved vertebral fracture height and kyphosis.Vertebral height loss and increased kyphotic deformity were observed in OVCF patients with endplate fractures after the surgery.Postoperative aggravation of kyphosis was observed in Group 2.Furthermore,severe vertebral height loss and increased kyphotic deformity were confirmed in Group 4 after the surgery.Our results suggested that postoperative vertebral height loss and aggravation of kyphosis may be associated with biomechanical changes in the vertebral body caused by endplate fr

英文摘要:

This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture (OVCF), who received balloon kyphoplasty. Patients were divided into four groups: Group 1 had no superior endplate fracture, Group 2 had fractures on the anterior portion of the superior endplate, Group 3 had fractures on the posterior portion of the superior endplate, and Group 4 had complete superior endplate fractures. Anterior and middle vertebral body height, vertebral compression ratio, vertebral height loss rate, and kyphosis Cobb angle of each patient were measured and visual analogue scale (VAS) and Oswestry disability index (ODI) scores were recorded. The anterior vertebral height and kyphosis deformity of all groups significantly improved after the surgery, whereas substantial anterior vertebral height loss and increased Cobb angle were observed in all patients at the last follow-up. Although the vertebral height loss rate and the Cobb angle in Group 2, 3 and 4 were larger compared with Group 1 at the last follow-up, only the vertebral height loss rate in Group 4 and the increase in the Cobb angle in Group 2 and 4 were statistically different from those in Group 1. The VAS and ODI scores in all groups measured after the surgery and at the last follow-up were significantly lower compared with preoperative scores, but there was no significant difference among these groups. Balloon kyphoplasty significantly improved vertebral fracture height and kyphosis. Vertebral height loss and increased kyphotic deformity were observed in OVCF patients with endplate fractures after the surgery. Postoperative aggravation of kyphosis was observed in Group 2. Furthermore, severe vertebral height loss and increased kyphotic deformity were confirmed in Group 4 after the surgery. Our results suggested that postoperative vertebral height loss and aggravation of kyphosis may be associated with biomechanical changes in

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期刊信息
  • 《南京医科大学学报:自然科学版》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:南京医科大学
  • 主编:沈洪兵
  • 地址:南京市龙眠大道101号
  • 邮编:211166
  • 邮箱:nyxb@njmu.edu.cn
  • 电话:025-86869293 86869297
  • 国际标准刊号:ISSN:1007-4368
  • 国内统一刊号:ISSN:32-1442/R
  • 邮发代号:28-61
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),波兰哥白尼索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:18896