中文摘要：

正常细胞代谢所需的能量主要由线粒体氧化磷酸化产生的ATP提供,而肿瘤细胞即便氧供充足也偏好利用增强糖酵解供能。同时,肿瘤细胞对葡萄糖和谷氨酰胺的摄取利用也十分活跃。肿瘤缺氧微环境,癌基因的激活,线粒体功能的抑制以及如炎症、micro RNA等因素共同促成肿瘤细胞糖酵解代谢表型,它不仅为肿瘤细胞提供充足的ATP,还为新肿瘤细胞的构筑提供生物大分子原料,从而利于生长增殖。基于肿瘤能量代谢模式的内在分子机制研究,将揭开靶向肿瘤治疗的新局面。

英文摘要：

Normal cells rely primarily on mitochondrial oxidative phosphorylation to generate ATP for the energy of metabolic activities. However, tumor cells prefer to exploit enhanced glycolysis for energy demand even if there is sufficient oxygen supply. Moreover, the uptake and utilization of glucose and glutamine in tu- mor cells are quite active. Hypoxic tumor microenvironment, oncogene activation, inhibition of mitochondrial function and other factors such as inflammation, microRNA contribute to the glycolytic phenotype of tumor cells. It not only provides enough ATP for tumor cells, but also provides biological macromolecular raw ma- terials for the construction of new tumor cells, both of which could promote tumor cells grow and proliferate. Researches on the intrinsic molecular mechanisms which are based on the energy metabolism would open new prospects for tumor targeting therapy.