中文摘要：

在老鼠调查胖新陈代谢的特征的目的在比重低於脑脊髓液的组织缺氧环境适应以后的骨胳的肌肉。方法 Sprague-Dawley 老鼠随机被划分成 3 个组：控制组(H0 ) ， hypoxic 5 天的组(H5 ) ，和 hypoxic 15 天的组(H15 ) 。H5 和 15 个组的动物暴露于比重低於脑脊髓液的组织缺氧房间模仿 5 000 m 高度为 5 d 或 15 d 的高度分别地， 23 h 每天。H0 组在房间外面留下来。丰满的酸氧化和举起的水平，和葡萄糖氧化被检验，并且丰满的酸(NEFA )(PCr ) ， ATP 和 phosphocreatine 也是的 non-esterified 的水平在老鼠的 assayed 骨胳的肌肉。在 H5 的 ATP 和 PCr 的内容组织的结果是比在 H0 和 H15 组的那些低的(P < 0.05 ) ，当 H0 和 H15 之间没有重要差别时。与 H0 相比，在所有组织缺氧组的血 NEFA 水平显著地被增加(P < 0.05 ) 。在 H15 组的肌肉 NEFA 水平是极大地比那高在 H0 和 H5 组。在 H15 组的丰满的酸氧化和举起的率比在 H0 和 H5 组的那些显著地高(P < 0.05 ) ，并且在所有组织缺氧组的葡萄糖氧化的率显著地在 H0 组比那被减少(P < 0.05 ) 。提高的胖氧化可以是在在比重低於脑脊髓液的 hypoxic 环境适应以后的精力动态平衡的维护的机制之一，这被结束的结论。

英文摘要：

Objective：To investigate the characteristics of fat metabolism in rat skeletal muscle after hypobaric hypoxia acclimation. Methods： Sprague-Dawley rats were divided into 3 groups randomly： control group （H0）, hypoxic 5-day group （HS）, and hypoxic 15-day group （H15）. Animals of H5 and 15 groups were exposed to hypobaric hypoxia chamber simulating 5 000 m high altitude for 5 d or 15 d respectively, 23 h per day. H0 group stayed outside of chamber The level of fatty acid oxidation and uptake, and glucose oxidation were examined, and the level of non-esterified fatty acids （NEFA）, ATP and phosphocreatine （PCr） were also assayed in rat skeletal muscles. Results： The contents of ATP and PCr in H5 group were lower than those in H0 and H15 groups （P〈0.05）, while there was no significant difference between H0 and H15. Compared with H0, the blood NEFA level in all hypoxia groups was increased significantly （P〈0.05）. The muscle NEFA level in H15 group was greatly higher than that in H0 and H5 groups. The rates of fatty acid oxidation and uptake in H15 group were significantly higher than those in H0 and H5 groups （P〈0.05）, and the rate of glucose oxidation in all hypoxia groups was significantly decreased than that in H0 group （P〈0.05）. Conclusion： It is concluded that the enhanced fat oxidation may be one of the mechanisms in the maintenance of energy homeostasis after hypobaric hypoxic acclimation.