黄芩来源于唇形科植物黄芩(Scutellariae baicalensis Georgi)的干燥根,具有清热燥湿,泻火解毒,止血,安胎的功效,在传统中医药及现代中药制剂中黄芩得以广泛应用。黄芩富含黄酮类化合物,其口服生物利用度较低,并且在肠道吸收过程中发生显著的首过效应。该文对近年来黄芩提取物及其主要活性组分药物动力学方面的研究进展加以综述,并讨论其未来研究中应注意的问题。
Radix Scutellariae is the dried root of Labiatae plant, Scutellariae baicalensis Georgi. It has broad therapeutic effects such as purging fire, moistening aridity, stoppage of bleeding and preventing miscarriage, and has been extensively applied in traditional medicine as well as modern pharmaceutics. Flavonoids are the major components in Radix Scutellariae, exhibiting low oral bioavailability due to the extensive first pass metab-olism during intestinal absorption. This paper reviews the research progress of the pharmacokinetics studies on the Radix Scutellariae extract and co-existing components and proposes the aspects which call for attention in its future research.