中文摘要：

目的：探讨慢性阻塞性肺疾病（COPD）肺动脉高压（PH）与血浆N末端B型脑钠肽原（NT-pro BNP）水平的相关性。方法：随机选取于本院诊治的COPD患者120例作为研究对象,其中COPD急性加重期患者（AECOPD）60例,简称A组;COPD合并PH期患者60例,简称B组。同时对B组进行肺动脉收缩压（PASP）检测并根据检测结果确定分组,其中PASP〈30mm Hg者为对照组,30mm Hg≤轻度组〈50mm Hg以及中重度组≥50mm Hg,观察并记录所有研究对象的血浆NT-pro BNP含量以及与PH的相关性。结果：B组血浆NT-pro BNPC水平远高于A组（P〈0.05）;中重度组NT-pro BNP水平显著高于对照组以及轻度组,三组两两相比具有统计学意义（P〈0.05）;血浆NT-pro BNP水平与PASP呈正相关（P〈0.05）。结论：NT-pro BNP水平与PH严重程度呈正相关,在临床判定PH严重程度方面具有一定的参考价值。

英文摘要：

Objective： To investigate the relationship between pulmonary arterial hypertension（ PH）and plasma levels of N terminal B type brain natriuretic peptide（ NT-proBNP） in patients with chronic obstructive pulmonary disease（ COPD）. Methods： 120 cases of patients with COPD treated in our hospital were selected as the study objects,and 60 cases of acute exacerbation of COPD patients were as group A,the other60 cases of COPD patients complicated with PH were as group B. At the same time,pulmonary systolic pressure（ PASP） was detected in group B,and grouped according to the test results. PASP level less than30 mm Hg were as the control group,between 30 mm Hg and 50 mm Hg were as the mild group,and more than or equal to 50 mm Hg were as the moderate and severe group. Plasma NT-proBNP levels and correlation with PH were observed and recorded of all the study objects. Results： Plasma NT-proBNPC level in group B was much higher than that in group A（ P〈0.05）. The level of NT-proBNP in moderate and severe group was significantly higher than that in the control group and the mild group,with statistically significant differences between every two groups of the three groups（ P〈0. 05）. Plasma NT-proBNP level was positively correlated with PASP（ P〈0.05）. Conclusion： NT-proBNP level is positively correlated with the severity of PH,and it has certain reference value in judging the severity of PH.