鸡传染性支气管炎病毒(IBV)的感染严重危害世界养鸡业,IBV在鸡体内的组织亲嗜性主要可分为呼吸型、肾型、嗜肠型、肌肉型、腺胃型和输卵管型等。不同组织亲嗜性的IBV毒株造成机体病理损伤主要部位有明显差异。IBV感染及组织和细胞嗜性的分子机理到底如何,目前尚未完全弄清楚。论文对IBV分子变异与毒力变化、细胞受体介导IBV感染及不同种类的体外细胞对IBV培养的不同特性等研究进展进行综述,旨在为IBV感染的组织亲嗜性及体外培养细胞感染的分子机制的研究提供参考。
Infection of infectious bronchitis virus(IBV)is seriously harmful to the world poultry industry.IBV in chicken in vivo tissue tropism can be divided into 6 types:respiratory type,kidney type,addicted intestinal type,muscular type,glandular type and fallopian tube type.Pathological lesions of the body′s main organs caused by IBV strains of different tissue tropism have significant differences.What is the molecular mechanism of IBV infection,its tissue and cellular tropism?It is not yet fully understood.In this paper,the brief advance in the relationship of IBV molecular variation and Changes in virulence,receptormediated cell IBV infections and IBV different characteristics due with different types of cells in vitro cultivation,were reviewed to provide a reference for the future research of the molecular mechanism of IBV infection and tissue tropism.