中文摘要：

p38丝裂原活化蛋白激酶（p38MAPK）信号通路是丝裂原活化蛋白激酶（MAPK）家族的一条重要途径，可被多种细胞外刺激而激活，近年来研究发现在细胞凋亡中发挥重要作用。p38MAPK可通过活化半胱天冬氨酸蛋白酶（caspase）家族成员、调节Bcl-2家族成员的活性、活化p53、参与Fas-FasL通路等多种途径介导肿瘤细胞的凋亡过程。

英文摘要：

p38 mitogen-activated protein kinases signaling pathway is an important way of Mitogen-activated protein kinases（MAPK） superfamily,which can be activated by diverse extracellular stimuli and plays a central role in cell apoptosis process, p38MAPK is involved in apoptosis of malignant tumor by activating caspase family members, regulating activities of Bcl-2 family members, activating p53, participating in Fas/FasL pathway and so on. This paper provides a brief review of p38MAPK,including structural characteristics, activity regulation and it＇ s role in apoptosis of malignant tumor.