中文摘要：

目的通过Meta分析评测老年骨质疏松性椎体压缩骨折（OVCF）椎体成形术（PVP）后继发骨折的相关因素。方法计算机检索Cochrane图书馆、PubMed、CNKI中国期刊全文数据库、中国生物医学文献数据库、万方数据库，并辅以手工检索、文献追溯相关文献，收集2006年1月至2016年9月国内外正式刊物上公开发表的有关老年OVCF患者行PVP术后继发骨折的中、英文文献，严格评价纳入研究的文献质量及提取相关数据资料，运用RevMan5．0软件统计分析所有相关数据。结果共纳入20项研究3602例患者，其中627例术后继发骨折。结果分析显示，术后继发骨折与患者骨密度值{WMD=-0．66，95％ct（-0．97，-0．36），P〈0．05]、初次术后脊柱节段后凸角[WMD：4．51，95％Cl（3．02，6．00），P〈0．05]有关，而与性别[OR=0．98，95％Ct（O．77，1．25）。P〉0．05]、年龄[WMD=1．48，95％Cl（-0．13，3．09），P〉0．05]、体重指数[WMD=-0．76，95％CI（-1．61，0．08），P〉0．05]、骨水泥注入量[WMD=-0．15，95％CI（-0．60，0．30），P〉0．05]、术中骨水泥渗漏方式[OR=1．11，95％CI（O．56，2．22），P〉0．05]、初次手术强化椎体节段数量[OR=0．74，95％cKo．09，6．45），P〉0．05]、原发骨折是否为胸腰段[OR=0．86，95％cKo．63，1．18），P〉0．05]、骨水泥注射入路[OR=1．58，95％CI（O．74，3．37），P〉0．05]无关。结论患者骨密度值、初次术后脊柱节段后凸角与椎体压缩骨折PVP术后继发骨折密切相关；而性别、年龄、体重指数、骨水泥注入量、术中骨水泥渗漏、初次手术强化节段数量、原发骨折是否为胸腰段、骨水泥注射入路等尚无足够的证据与椎体继发骨折有关。

英文摘要：

Objective To identify the risk factors for the fractures secondary to percutaneous ver- tebroplasty for osteoporotic vertebral compression fractures. Methods A comprehensive search was conducted for the studies from January 2006 to September 2016 on the risk factors for secondary fractures after percutaneous vertebroplasty in the Cochrane Library, PubMed Data, CNKI, Chinese Biomedical Database, Wanfang Data and manually as well. After retrieval of the eligible data, software RevmanS. 0 was used to perform the heterogeneity test and calculate the pooled odds ratio （OR）, weighted mean difference（WMD） value and 95% confidence interval （CI） . Results Twenty studies involving 3,602 patients, 627 of whom had fracture secondary to the surgery, were included in this meta-analysis. Meta-analyses showed the secondary fracture after percutaneous vertebroplasty for osteoporotic vertebral compression fracture was related to bone mineral density [ WMD = -0. 66, 95% CI （ -0. 97, -0.36）, P 〈 0. 05] and kyphosis after pri- mary operation [ WMD =4.51, 95% CI （3.02, 6.00）, P 〈 0. 05], but not to gender [ OR =0. 98, 95% CI （0.77, 1.25）, P〉 0.05], age [WMD=l.48, 95%CI （-0.13, 3.09）, P〉 0.05], body massindex [WMD= -0.76, 95% CI（-1.61, 0.08）, P〉 0.05], cement volume [WMD= -0.15, 95%CI （-0.60, 0.30）, P〉0.05], intradiscal cement [OR=I. ll, 95%CI （0.56, 2.22）, P〉0.05], number of vertebrae primarily treated [0R=0.74, 95% CI （0.09, 6.45）, P〉 0.05], thoracolumbar spine [ OR =0. 86, 95% CI （0. 63, 1.18）,-P 〉 0. 05], or cement injection approach ] OR = 1.58, 95% CI （0. 74, 3.37）, P 〉 0. 05 ]. Conclusions Bone mineral density and kyphosis after primary operation may be the risk factors closely correlative to the secondary fracture after percutaneous vertebroplasty. There has not been enough evidence to support the associations between the secondary fracture and gender, age, body mass index, cement volume, intradiscal cement, number of vertebrae primarily treated, thoracolum