中文摘要：

Micro RNA作为非编码小RNA分子在转录和后转录水平调控基因表达过程中扮演重要角色,已成为当前分子生物学的研究热点之一。近期已有研究证实,一些在肌肉细胞中特异表达micro RNA包括mi R-1、mi R-206和mi R-133可能对肌肉生长和发育很关键。众所周知,肌肉不仅是机体重要结构组织和运动器官,而且还是水产畜牧产品的重要蛋白源。聚焦这些肌肉特异myomi Rs在肌肉生长和发育中的功能机理研究,不仅有助于揭示某些疾病的分子机制和解决医学上基因治疗难题;同时也为畜牧水产养殖提供科学应用理论依据。综述我们概括了mi R-1,mi R-206和mi R-133最新研究进展,这将有助于深入了解其作用于肌肉生长和发育的功能和分子机制。

英文摘要：

Micro RNAs are small non-coding RNA molecules that play important roles in the transcriptional and post-transcriptional regulation of gene expression. Micro RNAs have become one of the hotspot issues in molecular biology. Recently several micro RNAs have been identified including mi R-1, mi R-206 and mi R-133 that are specifically expressed in muscle cells and may be crucially involved in the development and growth of muscles. Muscles are an important part of body structure as well as a locomotive organ, and they are also the main protein source in aquaculture and animal husbandry. Therefore, functional studies of the roles of muscle-specific micro RNAs will help uncover the mechanisms of certain diseases, facilitate medical gene therapy, and provide guidance for the animal husbandry and fishery. In this review we summarized the latest research on mi R-1, mi R-206 and mi R-133 that shed lights on better understanding of their functions in muscle development and growth.