中文摘要：

目的 探讨帕金森病（Parkinson disease,PD）患者的认知功能与血糖水平的关系。方法纳入PD患者200例,进行简易精神量表（mini-mental state examination,MMSE）、蒙特利尔认知量表（Montreal cognitive assessment,Mo CA）、韦氏智力和韦氏记忆的认知评估。将200例PD患者分为PD认知正常组91例,PD认知障碍组109例;另外纳入126例正常对照;比较各组的空腹血糖（fasting plasma glucose,FPG）、餐后2 h血糖（2 h postprandial plasma glucose,2 h PPG）和糖化血红蛋白（glycosylated hemoglobin,HbAlc）水平及糖尿病患病率,并采用二分类logistic回归分析血糖水平对PD患者认知功能的影响。结果 PD患者的FPG、HbAlc水平及糖尿病患病率[5.19（0.72）,5.7%（0.5%）,14%]都比正常对照组[4.85（0.79）,5.6%（0.5%）,6%]显著升高（P〈0.05）。PD认知障碍患者的FPG水平[5.21（1.32）]较PD认知正常组[4.81（0.95）]相比,显著升高（P〈0.05）,而2 h PPG、HbAlc都稍有升高,但无统计学差异（P〉0.05）。二分类logistic回归分析显示,FPG（OR：1.764;95%CI：0.06~3.244;P=0.068）与PD患者认知功能受损相关无统计学意义。结论 高血糖可能是PD的危险因素之一,本研究未发现PD患者认知障碍的发生与血糖水平相关。

英文摘要：

Objective To study the relationship between level of plasma glucose and cognitive function in pa- tients with Parkinson＇s disease. Methods Two hundred PD patients were assessed cognitive function using Mini-Men- tal State Examination （MMSE）,Montreal Cognitive Assessment （MoCA）, Wechsler Intelligence Scale and Wechsler Mem- ory Scale. The patients were divided into cognitive normal group （n=91） and cognitive impairment group （n=109）. One hundred twenty-six normal subjects were enrolled as control group （n=126）. The levels of fasting plasma glucose （FPG）, postprandial plasma glucose （2hPPG）, glycosylated hemoglobin （HbAlc） and the prevalence of diabetes mellitus were compared among the groups. The effect of blood glucose level on the cognitive function of PD patients was ana- lyzed by Binary Logistic Regression. Results The levels of FPG, HbAlc and the prevalence of diabetes mellitus [5.19 （0.72）, 5.7% （0.5%）, 14%] were significantly higher than those in the normal control group [4.85（0.79）, 5.6% （0.5%）, 6% ] （P〈0.05）. The levels of FPG in PD patients with cognitive impairment [5.21 （1.32）] was significantly higher than that in PD patients with cognitive normal group [4.81 （0.95）1 （P〈O.05）. Although 2hPPG and HbAlc increased slightly in PD patients with cognitive impairment , the difference did not reach an significant level （P〉0.05）. Binary Logistic Regression analysis showed that FPG（OR： 1.764; 95% CI： 0.06-3.244; P=0.068） was not associated with the impaired cognitive function in PD patients. Conclusion The present study has not revealed an association between the inci- dence of cognitive impairment in patients with PD and plasma glucose level although high plasma glucose may be a high risk factor for PD patients.