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Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers
  • ISSN号:1000-0720
  • 期刊名称:《分析试验室》
  • 时间:0
  • 分类:O641.3[理学—物理化学;理学—化学] S965.112[农业科学—水产养殖;农业科学—水产科学]
  • 作者机构:[1]Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China, [2]Department of Pharmacy, Northwest Hospital, Xi'an 710004, PR China, [3]Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China, [4]Xian Yang Central Hospital, Xian Yang 71200, PR China
  • 相关基金:This work was financially supported by the National Natural Science Foundations of China (no. 30873193 and no. 81173024) to professor Q. Fu. The authors also express their gratitude to professor Jun Haginaka from Mukogawa Women's University for his great help in the polymer preparation,
中文摘要:

In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.

英文摘要:

In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentra- tion with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.

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期刊信息
  • 《分析试验室》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:北京有色金属研究总院 中国有色金属协会
  • 主编:屠海令
  • 地址:北京新街口外大街2号
  • 邮编:100088
  • 邮箱:analysislab@263.net
  • 电话:010-82013328
  • 国际标准刊号:ISSN:1000-0720
  • 国内统一刊号:ISSN:11-2017/TF
  • 邮发代号:82-431
  • 获奖情况:
  • 综合性分析化学刊物,中文核心期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:25540