中文摘要：

目的观察腹腔注射氯化锂对根性神经痛模型大鼠痛行为的影响。方法制作注射式背根神经节压迫的根性神经痛模型。40只雄性SD大鼠随机分为模型组和假手术组（S组，n=12），模型组进一步随机分为溶剂对照组（C组，n=12）、早期治疗组（E组，n=8）、晚期治疗组（L组，n=8）。S组和C组在制模后第2，3，4，12，13，14天腹腔给予生理盐水；E组于制模后第2，3，4天给予氯化锂，第12，13，14天给予生理盐水；L组于制模后第2，3，4天给予生理盐水，第12，13，14天给予氯化锂。所有的实验大鼠在制模前1天、制模后第1，4，7，10，14，17，21天检测痛行为指标，包括机械缩足阈值（Paw withdrawal mechanical threshold，PWMT）和热缩足潜伏期（Paw withdrawal thermal latency，PWTL）。结果制模后1dC组PWMT、PWTL值较S组和基础值明显缩短，组问有统计学差异（P〈0．05）。腹腔注射氯化锂后，在制模后第4天，E组大鼠PWMT[（14．607±0.280）g]、PWTL[（19．940±0．933）S]较C组PWMT[（7．712±0．237）g]、PWTL[（8．190±0．382）s]显著增高（P〈0．05）；制模后第14天，L组大鼠PWMT[（11．700±0．379）g]、PWTL[（18．524±1．060）S]较C组PWMT[（6．788±0．331）g]、PWTL[（7．301±0．481）S]显著增高（P〈0．05），这种痛行为学的改善均持续到制模后第21天，但均未能恢复到假手术组水平（P〈0．05）。结论腹腔注射氯化锂可以有效改善慢性背根神经节压迫的根性神经痛大鼠的痛行为反应。

英文摘要：

Objective To investigate the analgesic effects of intraperitoneal lithium chloride injection on radicular pain behaviors in rats. Methods Using rat model of radicular pain induced by chronic compression of dorsal root ganglion（CCD） ,40 male SD rats were randomly divided into model group and Sham-operation group （group S, n = 12） of radicular pain were established. The rats in the model group were subdivided randomly into Control group（ group C, n = 12）, Early treatment group（ group E, n = 8） and Later treatment group （group L, n = 8 ）. Rats in group E were intraperitoneal injected with lithium chloride once daily on day 2 -4 after CCD respectively ,while rats in L,group C and S treated with Vehicle（0.9% NaC1）. Rats in L group were intraperitoneal treated with lithium chloride on day 12 - 14 after CCD respectively,while rats in E, group C and S received Vehicle. The pain ethology indexes such as paw withdrawal mechanical threshold （PWMT） and paw withdrawal thermal latency （PWTL） were tested on day 1 before operation and day 1,4,7,10,14,17 and 21 after operation. Resuits Compared to S group and preoperative level,PWMT and PWTL decreased at Day 1 postoperative in group C （P 〈 0.05 ）. At day 4 after the operation, compared with group C （7.712 ± 0. 237 ） g and （ 8.190 ± 0.382） s, PWMT and PWTL of E group increased to （ 14. 607 ± 0,280） g and （ 19. 940 ± 0. 933 ） s （P 〈 0.05 ） after intraperitoneal injected lithium chloride. At day 14, compared with group C （6. 788 ± 0. 331 ） g and （7. 301 ± 0. 481 ） s, PWMT and PWTL of group L increased to （ 11. 700 ±0. 379 ） g and （ 18. 524 ± 1. 060） s （P 〈 0.05 ）. This analgesic effect of lithium chloride continued to exist at day 21. However, there was still a significant Differenee between S group and E, group L（P 〈 0.05 ）. Conclusion Intraperitoneal lithium chloride injection alleviates pain behavior on radienlar pain in rats.