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中文摘要：
DNA甲基化是表观遗传修饰的重要部分,基因异常甲基化在肿瘤发生、发展中扮演重要角色。众多研究结果表明单核苷酸多态性（single nucleotide polymorphism,SNP）与DNA甲基化之间存在密切联系,可能通过改变甲基化位点或对DNA甲基化相关酶类产生影响,继而影响到相关基因的甲基化状态,改变表达水平,导致肿瘤易感性发生变化。DNA甲基化代表的表观遗传与SNP代表的遗传突变能为癌变的分子机制研究提供更多的理论支持。
英文摘要：
DNA methylation is one of the most important part in epigenetic modifications,and aberrant gene methylation plays a critical role in tumorigenesis.Many studies have indicated that DNA methylation is related to single nucleotide polymorphism（SNP） which may modify the methylation sites or influence the biological function of enzymes related to DNA methylation,change the status of genes＇ methylation,wihch in turn,contribute to tumorigenesis.The role of epigenetic（such as DNA mehtylation） and mutation（such as SNP） can provide more information for molecular metabolism in the carcinogensis.
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