中文摘要：

目的：快速阐明中药复方小续命汤的化学组成。方法：利用超高效液相色谱串联四级杆飞行时间质谱联用技术（UPLC/Q-TOF-MSE）对小续命汤有效成分组进行了快速分析和成分鉴定。液相条件：Waters ACQUITY UPLC HSS T3色谱柱（100 mm×2.1 mm，1.8 μm），以0.1%甲酸水-乙腈为流动相进行梯度洗脱，柱温40 ℃，流速0.35 mL·min-1；质谱条件：采用ESI源，正、负离子模式下分别进行数据采集。结果：通过与对照品信息的提取辨识、与数据库数据的匹配指认以及对文献资料的比照分析，从小续命汤有效成分组中鉴定了42个化合物，主要包括黄酮、生物碱、三萜皂苷等类成分，并归属了各化合物的单味中药来源。结论：本研究比较全面地阐明了小续命汤有效成分组的化学组成，为此中药复方的质量控制提供参考，也为其深入的药效物质基础及药理作用研究奠定了基础。

英文摘要：

Objective：In order to clarify the chemical composition and the source of active component Xiao-Xu-Ming decoction （AF-XXMD） quickly and comprehensively，whole and individual herbs of AF-Xiao-Xu-Ming decoction were analyzed by Ultra-Performance Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry（UPLC/Q-TOF-MSE）.Methods：Under identical experiment conditions，chromatography results were compared between experiment groups.A Waters ACQUITY UPLC HSS T3 column （100 mm×2.1 mm，1.8 μm） was used with 0.1% formic acid solution （A） -acetonitrile （B） as the mobile phase for gradient elution.The flow rate was set to 0.35 mL·min-1 and the column temperature was maintained at 40 ℃.Electrospray ion （ESI） source was applied for the qualitative analysis under the positive and negative ion mode.Results：Finally，based on comparison with standard samples，database matching analysis and reviewing relevant literature，42 compounds were identified from AF-Xiao-Xu-Ming decoction.The results implied that flavonoids，alkaloids and triterpenoid saponins were the main components in the effective part of AF-Xiao-Xu-Ming decoction.The herbal sources of these peaks were assigned.Conclusion：This established method is simple and rapid for elucidation the constituents of AF-Xiao-Xu-Ming decoction and the results could be used for the quality control and the further material basis research for AF-Xiao-Xu-Ming decoction.