中文摘要：

[目的]观察抑肝扶脾清热利湿法对广东地区腹泻型肠易激综合征（diarrheatypeirritablebowelsyn—drome，IBS-D）患者血浆胃动素（MTL）、血管活性肠肽（VIP）、生长抑素（SS）、胆囊收缩素（CCK）的影响，并探讨其作用机制。[方法3160例IBS-D患者随机分为2组，中药组采用易激灵2号方，煎取200ml，早晚分服；西药组口服马来酸曲美布丁片（商品名：舒丽启能）0．1g／次、枯草杆菌二联活菌肠溶胶囊（商品名：美常安）0．5g／次，3次／d；2组疗程均为4周。另选20例健康体检者为正常对照组。[结果]IB孓D患者血浆CCK、MTL水平较正常对照组明显增高（P〈O．01）；中药组和西药组自身疗后比较，血浆CCK、MTL水平明显降低（P〈O．01，P％0．05）；中药组治疗后血浆MTL水平较西药组明显降低（P〈O．05）。[结论]抑肝扶脾清热利湿法很可能是通过影响患者胃肠激素水平，达到治疗目的。

英文摘要：

[Objective] To observe the effect of soothing liver and invigorating spleen, clearing away heat and eliminating dampness on MTL,VIP, SS,CCK in patients with diarrhea type irritable bowel syndrome （IBS-D） in Guangdong. [Methods]The total of 160 patients with IBS-D were assigned to 2 groups：Chinese medicine Group was treated with YIJILING-2, decocted 200 ml, twice daily by oral administration;Western medicine Group was treated with Trimebutine Maleate Tablets 0. lg and Mei changan0. 5g, 3 times daily by oral administration. The therapeutic course was 4 weeks for all. [Results ] The plasma CCK, MTL were sig- nificantly higher in IBS-D patients than in the normal group（P〈0.01）. After treatment,the plasma CCK, MTL were significantly lower in IBS-D patients of Chinese medicine group and western medicine group（P 〈0.01, P〈0.05）, but the plasma MTL in Chinese medicine group was significantly lower than in the western medicine group （P〈0. 05）. [Conclusion] Methed of soothing liver and invigorating spleen,clearing away heat and eliminating dampness could perhaps influence the standard of gastrointestinal hormone and tread the IBS-D effectively.