中文摘要：

目的 构建经典型热射病（HS）大鼠模型，观察恢复期核心体温的调节特征，并分析其与预后的关系。方法 雄性SPF级SD大鼠60只随机分为HS组（n=50）和正常对照组（n=10）。HS组大鼠予39℃热打击，监测核心体温及动脉收缩压（SBP）变化，达到HS诊断标准后结束热打击，观察72h恢复期核心体温的变化特征及生存情况，并对预后因素进行单因素和多因素Cox回归分析。结果 HS组大鼠在热打击后恢复期表现为双相式变化，即发生低体温和迟发性高热。单因素分析显示，HS大鼠最高核心体温、最低核心体温均与预后相关（P〈0.05）。多因素分析显示，HS大鼠最高核心体温（P=0.000，HR=102.386）、恢复期最低核心体温（P=0.001，HR=0.134）为影响HS大鼠预后的独立危险因素。结论 大鼠达到HS时核心体温越高，其发生低体温的程度越深，预后越差。热应激期和恢复期核心体温水平可作为HS大鼠预后的敏感指标。

英文摘要：

Objective To construct classic heat stroke rat models, and observe the changes of body temperature in the recovery period after heat stress to explore its relationship with prognosis. Methods Sixty male SD rats were randomly divided into heat stroke group （HS group, n=50） and control group （C group, n=10）. Rats in HS group were exposed to 39℃ heat stress. Core temperature and systolic blood pressure （SBP） of rats were monitored until it reached diagnostic criteria of heat stroke. The core body temperature and survival were continuously monitored until 72h. The risk factors of survival were analyzed by univariate and multivariate Cox regression analyses. Results During the recovery, compared with the control group, the body temperature of the HS rats represented a biphasic change that consisted of an initial hypothermia and a delayed hyperthermia. Univariable analysis showed that both the highest and lowest core body temperatures were correlated with prognosis in the heat stroke rats （P〈0.05）. Multivariate analysis revealed that both the highest core body temperature （P=0.000, HR=102.386） and lowest core body temperature in the recovery period （P=0.001, HR=0.134） were the independent risk factors for heat stroke. Conclusion In heat stroke rats, the higher the core body temperature and the deeper the depth of hypothermia, the poorer the prognosis. Core body temperature in heat stress and recovery period could serve as prognostic indexes in heat stroke.