中文摘要：

目的探讨肠系膜淋巴管结扎对重症中暑大鼠凝血功能的影响。方法 40只雄性Wistar大鼠均分为5组（n=8）：正常对照组、热应激对照（HSS）组、热应激对照肠系膜淋巴管结扎（HSS-LDL）组、重症中暑（SHS）组和重症中暑肠系膜淋巴管结扎（SHS-LDL）组。制备重症中暑大鼠模型,重症中暑发生时采集外周血行凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）等凝血相关指标的检测,同时对肺脏和肾脏进行组织病理分析。结果与正常对照组比较,HSS组、HSS-LDL组大鼠凝血指标均无明显变化,而SHS组大鼠PT和APTT均明显延长（P〈0.05）,血小板（PLT）计数明显下降（P〈0.05）,D-二聚体明显升高（P〈0.05）,SHS-LDL组大鼠所有凝血指标呈现部分恢复趋势（P〈0.05）。组织病理学分析提示SHS组大鼠肺脏和肾脏呈现严重出血、淤血等病理损害,肠系膜淋巴管结扎部分缓解了脏器组织的出血性病理损害。结论肠淋巴途径的肠源性毒性物质可能是造成重症中暑全身和脏器凝血功能紊乱的重要原因,肠系膜淋巴管结扎可部分缓解凝血功能紊乱的发生。

英文摘要：

Objective To investigate the inl uences of mesenteric lymph duct ligation（LDL） on the coagulation function in rats with severe heat stroke（SHS）. Methods Forty male Wistar rats were randomly and equally divided into control, heat stroke sham（HSS）, HSS-LDL, severe heat stroke（SHS） and SHS＋LDL groups. Mesenteric lymph ducts were ligated in HSC-LDL and SHS-LDL groups before reproduction of SHS model. SHS rat models were reproduced in a prewarmed incubator. Peripheral blood was drawn to determine the parameters pertaining to blood coagulability including prothrombin time（PT）, activated partial thromboplastin time（APT）, D-dimmer and platelet count（PLT）, and lung and kidney histopathology was observed at er heat stroke. Results Compared with those in control group, no obvious changes were observed in the coagulation indices in HSS and HSS-LDL group. While PT and APTT significantly prolonged, PLT remarkably decreased, D-dimmer markedly increased in SHS group（P0.05）. h e coagulation indices presented a recovery trend to certain extent in SHS-LDL group. Histopathological examination of the kidney and lung showed severe hemorrhagic and congestive lesions in SHS group. Mesenteric lymph duct ligation alleviated the coagulation disorders and histopathological lesions. Conclusion h e entrance of toxic agents through lymphatic passage may be the pathogenetic factor in producing coagulopathy, and ligation of the mesenteric lymph ducts might prevent the entrance of toxic materials and alleviate the injury to the blood coagulation property and internal organs.