中文摘要：

目的：探讨慢性愤怒应激对大鼠衰老进程的影响及其神经内分泌免疫机制。方法：在D-半乳糖（D-gal）衰老及脑老化模型基础上引入愤怒刺激,观察慢性愤怒应激对大鼠空间学习记忆能力的影响; 测定脑组织及血清去甲肾上腺素（NE）、五羟色胺（5-HT）含量、血清皮质酮（CORT）水平以及脾脏指数。结果：与D-gal组比较,愤怒D-gal大鼠空间学习记忆能力下降; 脑组织和血清NE升高、5-HT降低; 血清CORT水平升高; 脾脏指数下降。结论：慢性愤怒应激加重D-gal大鼠的衰老及脑老化程度,加速衰老进程。HPA轴和SAS持续兴奋,神经内分泌紊乱和免疫功能抑制是其可能的机制。

英文摘要：

Objective： To investigate the effects of chronic anger stress on rats＇ aging process and the mechanism of the neurnendocrine-immune network. Methods： After the aging and brain aging rats induced by D-gatactose（D-gal） were stimulated by anger, observation of the effects of chronic anger stress on the rats＇ spatial learning and memory was made, the contents of norepinephrine （ NE ） , 5-hydroxytryptamine （ 5-HT ） in brain tissue and serum, the levels of adrenocorticotropic hormone （CORT） in serum were assayed, the spleen index was measured. Results： Compared with the D-gal group, in the D-gal group stimulated by anger, the rats＇ ability of spatial learning and memory declined, the contents of NE in brain tissue and serum increased, the contents of 5-HT declined, the levels of CORT in serum increased, and the spleen index declined. Conclusion： The rats＇ aging and brain aging were aggravated and the aging process were accelerated by chronic anger stress. The possible mechanism were the sustained excitability of the HPA axis and SAS, disturbances of neuroendocrine system and immunological function repression.