中文摘要：

目的检测肺鳞癌组织中膜联蛋白Ⅰ（Annexin-1,Anx-A1）的表达水平,探讨其临床意义。方法采用实时荧光定量PCR（RQ-PCR）和Western blot方法检测22例肺鳞癌组织及其相应癌旁正常组织中Anx-A1 mRNA及蛋白的表达水平,并分析其与临床病理指标的关系。结果肺鳞癌组织中Anx-A1 mRNA和蛋白的表达水平均高于癌旁正常组织,在低分化肺鳞癌组织中的表达水平高于高、中分化肺鳞癌组织,差异具有统计学意义（P〈0.05）。Anx-A1在早期（Ⅰ期＋Ⅱ期）肺鳞癌组织和非早期（Ⅲ期）癌组织中表达水平的差异无统计学意义（P〉0.05）。结论 Anx-A1在肺鳞癌中表达上调,可能与肺癌的发生、发展相关。

英文摘要：

Objective To investigate the expression and significance of Annexin-1（Anx-A1） mRNA and protein in lung squamous carcinoma tissues.Methods Quantitative real-time PCR（qRT-PCR） and Western blot were used to detect Anx-A1 mRNA and protein levels in 22 cases of lung squamous carcinoma and corresponding adjacent normal tissues.The relationship between expressional levels and pathological characters was analyzed.Results The expression levels of Anx-A1 mRNA and protein in lung squamous carcinoma were significantly higher than those in adjacent normal tissues.The expression level of Anx-A1 in poor differentiated tissues was higher than that in middle and high differentiation tissues of lung squamous cell carcinoma（P0.05）.No expression difference between stage Ⅲ tumor tissues and stageⅠ～Ⅱ tissues was detected（P0.05）.Conclusion Up-regulated expressions of Anx-A1 mRNA and protein in lung squamous cell carcinoma tissue might contribute to lung carcinogenesis.