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中文摘要：
热激蛋白gp96可特异性结合来源于肿瘤和病毒的抗原肽,与抗原呈递细胞表面CD91等受体作用进入胞内,并在内质网中将结合的抗原通过抗原呈递链呈递给MHCI类分子,激活特异性T细胞。同时,与细胞表面Toll样受体（TLR）TLR2、TLR4等相互作用,激活天然免疫。近期研究发现调节性T细胞（Treg）对gp96免疫功能有显著抑制作用,随着对影响gp96免疫功能的免疫抑制机制的深入了解,以及利用汉逊酵母表达有免疫活性的全长gp96蛋白体系的建立,gp96将在治疗肿瘤及传染性疾病中发挥更大的作用。
英文摘要：
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus.Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface,and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation.Meanwhile,gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4.Recent studies have shown a gp96-mediated immune balance between CTL and Tregs.With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses,and establishment of high level production of recombinant gp96 by the yeast,gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
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