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Frequency-specific abnormalities in regional homogeneity among children with attention deficit hyperactivity disorder： a resting-state fMRI study

ISSN号：1005-2224
期刊名称：《中国实用儿科杂志》
时间：0
分类：Q959.848[生物学—动物学] O571[理学—粒子物理与原子核物理;理学—物理]
作者机构：[1]Peking University Sixth Hospital/Institute of Mental Health,Beijing 100191, China, [2]Key Laboratory of Mental Health, Ministry of Health, PekingUniversity, Beijing 100191, China, [3]Center for Cognition and Brain Disorders, Hangzhou NormalUniversity, Hangzhou 311121, China, [4]Zhejiang Key Laboratory for Research in Assessment ofCognitive Impairments, Hangzhou 311121, China, [5]Academic Child Psychiatry Unit, Department of Pediatrics,University of Melbourne, Royal Children's Hospital, Melbourne,VIC 3052, Australia, [6]Developmental Imaging, Murdoch Childrens Research Institute,Department of Pediatrics, University of Melbourne, Melbourne.VIC 3052, Australia
相关基金：Acknowledgments This work was supported by the National Basic Research Development Program of China （2014CB846104）, the National Natural Science Foundation of China （81371496, 30970802, 81101014） and the Program for New Century Excellent Talents in University （NCET-11- 0013）. Dr. Zang is partly supported by the ＂Qian Jiang Distinguished Professor＂ Program.

作者： Xiaoyan Yu[1,2], Binke Yuan[3,4], Qingjiu Cao[1,2], Li An[1,2], Peng Wang[1,2], Alasdair Vance[5], Timothy J. Silk[6], Yufeng Zang[3], Yufeng Wang[1,2], Li Sun[1,2]

关键词：功能性磁共振成像, 同频率, 静息态, 异常, 异性, 儿童, 缺陷, 同质性, Attention deficit hyperactivity disorder（ADHD） , Resting state , Regional homogeneity（ReHo） , Frequency-specific

中文摘要：

尽管许多功能的磁性的回声成像(fMRI ) 研究调查了注意赤字活动过度混乱(ADHD ) 的神经生理学，存在研究没产出一致调查结果。这可能与不同频率乐队的不同性质有关。在 ADHD 调查自发的神经活动的频率特定的地区性的同质( ReHo )，当前的学习使用了休息状态 fMRI 探索五个频率乐队，的 ReHo 性质 slow-5 ( 0.01-0.027 ? Hz )， slow-4 ( 0.027-0.073 ? Hz )， slow-3 ( 0.073-0.198 ? Hz )， slow-2 ( 0.198-0.25 ? Hz )并且额外低的频率( 0-0.01 ? Hz )，在有 ADHD 和 30 健康控制的 30 个药天真的男孩。与控制相比， ADHD 组包括中间的前额的外皮和 precuneus 在缺省模式网络(DMN ) 显示出减少的 ReHo，中间的正面的回转和尖回转。ADHD 病人也在以后的小脑显示出增加的 ReHo。在频率乐队和组之间的重要相互作用在前额的 dorsolateral 和顶骨主要被观察 cortices，轨道的正面的外皮，增补马达区域，劣等的枕骨的回转，丘脑和前面的小脑。特别地，我们发现在额外低的频率乐队的在组之间差别(0-0.01 ? Hz ) 似乎在为大多数大脑区域的另外的频率乐队比那大。调查结果建议 ADHD 孩子在地区性的大脑活动显示普遍畸形，在特别地， DMN 和注意联网，并且这些畸形出现频率特性。

英文摘要：

Although many functional magnetic resonance imaging （fMRI） studies have investigated the neurophysi- ology of attention deficit hyperactivity disorder （ADHD）, the existing studies have not yielded consistent findings. This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity （ReHo） of spontaneous neural activities in ADHD, the current study used resting-state fMRI to explore the ReHo properties of five frequency bands, slow-5 （0.01-0.027 Hz）, slow-4 （0.027-0.073 Hz）, slow-3 （0.073-0.198 Hz）, slow-2 （0.198-0.25 Hz） and the extra-low frequency （0-0.01 Hz）, in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased ReHo in the default mode network （DMN） including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased ReHo in the posterior cerebellum. Significant interactions between frequency band and group were observed pre- dominantly in the dorsolateral prefrontal and parietal cor- tices, orbital frontal cortex, supplementary motor area, inferior occipital gyrus, thalamus and anterior cerebellum. In particular, we found that the between-group difference in the extra-low frequency band （0-0.01 Hz） seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity, particularly in the DMN and attention network, and these abnormalities show frequency specificity.

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