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Nanostructured hollow spheres of hydroxyapatite： preparation and potential application in drug delivery

ISSN号：0251-0790
期刊名称：《高等学校化学学报》
时间：0
分类：TQ174.75[化学工程—陶瓷工业;化学工程—硅酸盐工业] O614.241[理学—无机化学;理学—化学]
作者机构：[1]School of Chemical Engineering, Hefei University of Technology, Hefei 230009, China, [2]Anhui Key Laboratory of Controllable Chemical Reaction & Material Chemical Engineering, Hefei 230009, China
相关基金：Acknowledgements The authors are grateful to the financial support of the National Natural Science Foundation of China （Grants Nos. 20871038, 20976033 and 21176054）, the Fundamental Research Fund for the Central Universities （2010HGZY0012） and the Education Department of Anhui Provincial Government （TD200702）.

作者： Xiaojing ZHANG[1,2] Weixin ZHANG[1,2] Zeheng YANG[1,2] Zhao ZHANG[1,2]

关键词：纳米羟基磷灰石, 纳米空心球, 药物输送, 应用, 场发射扫描电子显微镜, 透射电子显微镜, 编制, 药物控制释放, hydroxyapatite, hollow spheres, synthesis,drug release

中文摘要：

一个 solvothermal 方法成功地被用来准备 nanostructured hydroxyapatite (哈) 有大约 500 nm 的平均直径和在甘油 / 水的大约 100 nm 的壳厚度的空范围混合了溶剂。传播电子显微镜学(TEM ) 和 HA 空范围的壳实际上是的图象表演与大约 10 nm 的厚度 nanosheets 填写了的地排放扫描电子显微镜学(FESEM ) 。由调节甘油 / 水体积比率，有大约 6 或 20 m 的平均直径的二个其它种 HA 稳固的范围从 nanoflakes 被装配。药交货搬运人被评估的范围的不同类型的性质。布洛芬(IBU ) 被选择为模型药到负担进 HA 样品。nanostructured 哈样品显示出 IBU 的一个慢、支撑的版本。HA 空范围展出了比 HA 稳固的范围并且这样装载能力和更有利的版本性质的更高的药为控制的药版本应用是很有希望的。

英文摘要：

A solvothermal method has been successfully used to prepare nanostructured hydroxyapatite （HA） hollow spheres with average diameters of about 500 nm and shell thicknesses of about 100 nm in a glycerin/water mixed solvent. Transmission electron microscopy （TEM） and field-emission scanning electron microscopy （FESEM） images show that the shells of the HA hollow spheres are actually composed of nanosheets with thicknesses of about 10 nm. By tuning the glycerin/water volume ratio, two other kinds of HA solid spheres with average diameters of about 6 or 20 pm were assembled from nanoflakes. The properties of the different kinds of spheres as drug delivery carriers were evaluated. Ibuprofen （IBU） was chosen as the model drug to load into the HA samples. The nanostructured HA samples showed a slow and sustained release of IBU. The HA hollow spheres exhibited a higher drug loading capacity and more favorable release properties than the HA solid spheres and thus are very promising for controlled drug release applications.