中文摘要：

目的探讨hMSH2—118T〉C基因多态性与广东汉族妇女宫颈癌易感的相关性。方法采用分子流行病学研究方法，收集113例经病理学确诊为宫颈癌的新发患者为病例组，280例年龄相匹配的健康体检者作为对照组；采用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）分析技术，对hMSH2基因-118T〉C多态位点进行分型，采用非条件逻辑回归分析统计该多态位点与宫颈癌易感的相关性。结果病例组与对照组间基因型频率分布差异无统计学意义（P=0．91）；以TT基因型作为参照，TC、CC基因型均没有显著增加个体患宫颈癌的风险（OR分别为1．10和1．14，95％C1分别为0．69—1．77和0．34—3．82）。结论hMSH2基因-118T〉C多态性与广东汉族妇女宫颈癌易感性无关。

英文摘要：

Objective To investigate the relationship between the hMSH2-118T 〉 C polymorphism and the susceptibility of cervical cancer in ethnic Han Cantonese population. Methods The genotypes of the hMSH2-118T 〉 C polymorphism were determined in 113 cervical cancer patients and 280 age-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Association between the polymorphism and the risk for cervical cancer was evaluated using unconditional logistic regres- sion analysis. Results No significant difference was observed in the frequency of hMSH2-11ST 〉 C between cases and controls（P = 0.91 ）. Taking ＇IT genotype as reference, no significantly increased risk for cervical cancer was observed for those carrying TC or CC genotypes（OR = 1.10,95 %CI0.69-1.77;OR = 1.14,95 %CI0.34-3.82,respectively） . Conclusion ThehMSH2-118T〉 C polymorphism is not associated with the susceptibility of cervical cancer in ethnic Han Cantonese population.