位置：立项数据库 > 立项详情页
生物化学和分子生物学
  • 项目名称：生物化学和分子生物学
  • 项目类别：国家杰出青年科学基金
  • 批准号：30725008
  • 申请代码：C05
  • 项目来源：国家自然科学基金
  • 研究期限：2008-01-01-2011-12-31
  • 项目负责人：王俊
  • 负责人职称：研究员
  • 依托单位：深圳华大基因研究院
  • 批准年度：2007
中文摘要：

王俊教授多年来致力于基因组学研究，作为主导者或主要参与者参与多项重大基因组研究，主要工作成果包括带领科研团队研发先进的生物信息学分析方法，包括组装、注释、比对等各种数据分析工具，以应对测序技术的快速更新；应用比较基因组学及其他组学方法，对人类基因组、动植物基因组、癌症基因组及微生物基因组等多个领域进行系统研究，填补了多项基因组学研究空白，其科研成果多数以文章形式发表于国际顶级学术期刊，得到了国内外生命科学科学家的高度评价与肯定；建立基因组数据库，为后续基因组学研究提供数据支持；组织或参加多项世界前沿基因组学研究，促进了国内外科学技术的交流与沟通，推进了基因组学在生物医药及其它方面应用的进程。综上所述，王俊教授在基因组学研究方面积累了丰富的经验，自其研究生阶段开始，在国际专业期刊上共发表150余篇论文，其中在Science、Nature系列杂志上发表48篇(17篇为封面文章)，其中通讯或第一作者30篇（11篇为封面文章）。王俊教授在基因组学方面的持续探索与不断创新，为解密生命密码、加速基因组学技术的应用转化、维持人类的健康发展做出了杰出贡献。

中文主题词： 基因组学；生物信息学；比较基因组；基因组注释；进化
结论摘要：

英文主题词Genome; Bioinformatics;Comparative Genomics;Genome Annotation;Evolution

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 86
  • 0
  • 0
  • 0
  • 0
期刊论文
Analysis of 142 genes resolves the rapid diversification of the rice genus
Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of r
Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosom
Bisulfite Sequencing Reveals That Aspergillus flavus Holds a Hollow in DNA Methylation
Whole-genome sequence of Schistosoma haematobium
Personal genomes: for one and for all
Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across t
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Mapping copy number variation by population-scale genome sequencing
Genome-Wide Mapping of DNA Methylation in Chicken
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers
Comprehensive comparison of three commercial human whole-exome capture platforms
Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing
Classic selective sweeps were rare in recent human evolution
Systematic assessment of reduced representation bisulfite sequencing to human blood samples: A promi
Confirmation by Exome Sequencing of the Pathogenic Role of NCSTN Mutations in Acne Inversa (Hidraden
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de
Enterotypes of the human gutmicrobiome
Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese r
The genomic sequence of the Chinese hamster ovary (CHO)-K cell line
Ascaris suum draft genome.
Estimation of allele frequency and association mapping using next-generation sequencing data
An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social
Variation in genome-wide mutation rates within and between human families
The genome of the mesopolyploid crop species Brassica rapa
Building the sequence map of the human pan-genome
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and
Pig genome sequence - analysis and publication strategy
Metagenomics of the intestinal microbiota: potential applications
Faster human genome sequencing
SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology
The DNA Methylome of Human Peripheral Blood Mononuclear Cells
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variant
Ten years of genetics and genomics: what have we achieved and where are we heading?
Genome-wide patterns of genetic variation among elite maize inbred lines
Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell R
Whole genome DNA methylation analysis based on high throughput sequencing technology
De novo assembly of human genomes with massively parallel short read sequencing
Sequencing, annotation and comparative analysis of nine BACs of giant panda (Ailuropoda melanoleuca)
Design of Association Studies with Pooled or Un-pooled Next-Generation Sequencing Data
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
Genetic diversity, molecular phylogeny and selection evidence of the silkworm mitochondria implicate
Ancient human genome sequence of an extinct Palaeo-Eskimo
The sheep genome reference sequence a work in progress
Diversity of Human Copy Number Variation and Multicopy Genes
Genomic Comparison of the Ants Camponotus floridanus and Harpegnathos saltator
State of the art de novo assembly of human genomes from massively parallel sequencing data
A human gut microbial gene catalogue established by metagenomic sequencing
UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cycloo
Gene conversion in the rice genome
Analysis of expressed sequence tags from biodiesel plant Jatropha curcas embryos at different develo
Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large
Exome Sequencing Identifies ZNF644 Mutations in High Myopia
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
SNP detection for massively parallel whole-genome resequencing
Identification and characterization of novel amphioxus microRNAs by Solexa sequencing
The Schistosoma japonicum genome reveals features of host-parasite interplay
The YH database: the first Asian diploid genome database
The genome of the cucumber, Cucumis sativus L
Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer
Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx)
SOAP2: an improved ultrafast tool for short read alignment
Positive correlation between recombination rate and nucleotide diversity is shown under domestication selection in the chicken genome
40个基因组完全重测序揭示蚕的驯化事件及其相关基因
Evolutionary Transients in the Rice Transcriptome
相关项目
全基因组超高通量表观调控组学研究
期刊论文 12
多巴胺能神经元关键生物分子的研究及新分化模型的建立
期刊论文 3
柑桔属植物的分子系统学与进化研究
期刊论文 3
基于信息抽取技术的蛋白质相互作用网络构建及蛋白质复合物识别研究
期刊论文 33 会议论文 1
恒河猴功能基因组学研究与专家数据库构建及其在代谢综合症机制研究中的应用
期刊论文 9
进化与随机种群动力学模型
期刊论文 23 会议论文 5
蓝藻和红藻藻胆体中连接蛋白进化的生物信息学和比较蛋白质组学研究
期刊论文 6
野生稻匍匐生长习性基因克隆及分子进化的研究
期刊论文 1
疾病生物分子网络的系统建模与调控机理研究
期刊论文 36 会议论文 3 专利 2
王俊的项目
　全基因组高分辨率中国（东亚）人群遗传变异图谱的绘制
期刊论文 2
基于全基因组重测序方法的中国人群基因组多态性研究
期刊论文 30
猪基因组注释及全基因组基因芯片设计
期刊论文 16