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中文摘要：
总结了我国抗中性粒细胞胞浆抗体（ANCA）相关小血管炎的靶抗原有别于西方的特点，指出我国患者的ANCA以抗髓过氧化物酶（MPO）抗体为主；利用药物诱发的ANCA阳性小血管炎患者的"模型"，证明抗MPO抗体滴度和亲合力的提升以及抗内皮细胞抗体的出现是临床上发生小血管炎的危险因素。发现正常人血清中存在天然抗GBM抗体并明确了其靶抗原及抗原决定簇，证明了天然抗体向致病性抗体转换的过程中抗体的滴度和亲合力的提升、亚型转换的重要意义。上述研究工作不仅为疾病的发病机制补充了新的理论，同时也被用于协助临床诊断和治疗方案的制定。近5年发表SCI收录论文35篇，其中32篇为责任作者，接收待发表4篇，其中6篇发表在本领域最有影响的杂志《J Am Soc Nephrol》和《Kidney Int》。近5年内获得国家科技进步二等奖一次，获得中国青年科技奖并入选"新世纪百千万人才工程"国家级人选。
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期刊论文
Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxi
High potential to reverse the inhibition of myeloperoxidase by ceruloplasmin of anti-myeloperoxidase
IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with We
Differential deposition of C4d and MBL in glomeruli of patients with ANCA-negative pauci-immune cres
Complement deposition in renal histopathology of patients with ANCA-associated pauci-immune glomerul
The role of HLA-DRB1 alleles on susceptibility and severity of Chinese patients with anti-GBM diseas
Influence of myeloperoxidase by anti-myeloperoxidase antibodies and its correlation with the disease
The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) d
Renal neutrophil infiltration in antineutrophil cytoplasmic antibodies-negative pauci-immune crescen
The Immunopathological Spectrum of Crescentic Glomerulonephritis: a survey of 106 patients in a sing
The association of HLA-DRB1 alleles with antineutrophil cytoplasmic antibody-associated systemic vas
Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody a
Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are pr
Anti-Glomerular Basement Membrane Disease: Outcomes of Different Therapeutic Regimens in a Large Sin
Modified c-reactive protein might be a target autoantigen of tubulointerstitial nephritis and uveiti
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