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移植免疫学
  • 项目名称：移植免疫学
  • 项目类别：国家杰出青年科学基金
  • 批准号：30425026
  • 申请代码：H1006
  • 项目来源：国家自然科学基金
  • 研究期限：2005-01-01-2008-12-31
  • 项目负责人：赵勇
  • 负责人职称：研究员
  • 依托单位：中国科学院动物研究所
  • 批准年度：2004
中文摘要：

申请人在过去10余年主要从事T细胞分化与选择、移植免疫耐受（T细胞和NK细胞）及异种移植免疫学研究。科研工作主要有以下几点新意，可代表申请人的主要学术贡献①凭借MHC基因缺失、TCR转基因小鼠等移植动物模型，证实小鼠造血干细胞可在异种胸腺中进行正常分化、成熟为具有正常免疫功能的T细胞。②在无任何免疫抑制剂存在的情况下，使跨种属组织移植物(猪皮肤)在免疫功能健全的受者体内(小鼠)长期存活，成功地建立T细胞的异种移植

中文主题词： 移植免疫耐受;T 细胞;细
成果综合统计
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期刊论文
Development of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus grafts
Toll-like receptors and graft rejection
Specific immune tolerance of antigen-presenting cells: Hypothesis and significance
Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozocin-induced diabete
Toll样受体信号传导途经的研究进
实验动物胰岛细胞的分离纯化
小鼠Foxp3片段的表达和多克隆抗体的制备
BTLA, a new inhibitory B7 family receptor with a TNFR family ligand
Transforming growth factor-beta: An important role in CD4+CD25+ regulatory T cells and immune tolera
Dendritic cells induced in the presence of GM-SCF and IL-5
Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+ T cells in mice
Thymic epithelial progenitor cells and thymus regeneration: an update.
Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+CD
Allograft inflammatory factor-1 and its immune regulation
The influence of cyclosporine A on lymphocyte attenuator expression
The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells
The biological role of dectin-1 in immune response
Phagocytosis of apoptotic cells and immune regulation
The two simultaneously occurring processes in one immune response: The positive immune reaction and
转录因子高表达对小鼠淋巴瘤细胞周期和凋亡的影响
NKR-P1家族及其配体的研究
MOP3, a component of the molecular clock, regulates the development of B cells
The mortality of MOP3 deficient mice with a systemic functional failure
The nonopsonic allogeneic cell phagocytosis of macrophages detected by flow cytometry and two photon
Molecular cloning and characterization of a novel mouse actin-binding protein ZFP185
Deficiency of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus-grafted nude mice su
Mouse models with human immunity and their application in biomedical research
The effects of antibody treatment on regulatory CD4+CD25+ T cells
The inflammatory of Th17 subset in immunity against self and non-self antigens
The regulation of Foxp3 expression in regulatory CD4+CD25+ T cells: Multiple pathways on the road
CD4+ T细胞的新亚型：Th17细胞及其生物效应
A novel approach to generate host anti-tumor T cells: Adoptive immunotherapy by T cells maturing in
The diverse biofuctions of LIM domain proteins: determined by subcellular localization and protein-p
The immunity of splenic and peritoneal F4/80+ resident macrophages in mouse mixed allogeneic chimera
The different effects of indirubin on effector and CD4+CD25+ regulatory T cells in mice: potential i
Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: Influence on regulatory CD4+CD25+Foxp3+ T
Induction of regulatory T cells from mature T cells by allogeneic thymic epithelial cells in vitro
Compatibility of porcine and human interleukin 2: implication for xenotransplantation
Presence of functional mouse regulatory CD4+CD25+ T cells in xenogeneic neonatal porcine thymus-graf
The effects of immunosuppression on regulatory CD4+CD25+ T cells: impact on immunosuppression select
Platelet aggregation and thrombosis in xenotransplantation between pigs and humans.
The macrophage heterogeneity: difference between mouse peritoneal exudates and splenic F4/80+ macrop
A potential side effect of Cyclosporin A: inhibition of CD4+CD25+ regulatory T cells in mice
CD4^＋T细胞的新亚型：Th17细胞及其生物效应
应用双光子显微镜和流式细胞仪定性及定量确定小鼠巨噬细胞的吞噬功能
T细胞的脂筏与免疫突触
非肥胖性糖尿病（NOD）小鼠模型及其发病免疫学机制
γ型干扰素、CD4^＋CD25^＋调节性T细胞与自身免疫病
著作
移植免疫耐受
异种移植
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赵勇的项目
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巨噬细胞作为效应细胞参与移植排斥反应及其机制研究
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期刊论文 10
髓系抑制性细胞亚群的诱导及其移植免疫耐受的意义
混合嵌合体小鼠巨噬细胞免疫耐受特征及其分子机制研究
期刊论文 2
混合嵌合体小鼠巨噬细胞特异免疫耐受及其机制基础研究
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