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中文摘要：
80年代以来，以张运院士为带头人的山东大学创新研究群体，立足于国家重大需求，对动脉粥样硬化和心力衰竭所致心血管重构的分子机制和干预策略进行了深入研究，发现了心血管重构的易患基因，建立了易损斑块和心力衰竭的动物模型，揭示了心血管重构的分子机制，发展了检测易损斑块和心脏功能的新技术，发现了治疗心血管重构的多个新靶点。承担国家和省部级重点和计划研究课题100余项，在国内外发表论文446篇，其中SCI收录255篇，累计影响因子1047，被SCI杂志引用4050次，其中团队骨干作为通讯作者发表论文被SCI杂志引用1060次。获国家科技进步二等奖2项，三等奖3项，何梁何利基金科技进步奖1项，山东省科学技术最高奖1项，省部级科技进步一等奖8项，二等奖25项。该群体拟从整体、器官、细胞和分子水平的不同层次，继续深入研究心血管重构的分子机制和干预策略，以达到提高心血管病防治水平和降低心血管病死亡率的最终目的
英文摘要：
atherosclerosis；heart failure；cardiovascular remodeling；molecular mechanisms；innovative research group
结论摘要：
张运院士领导的创新研究群体科学基金项目《心血管重构分子机制和干预策略研究》，经过三年的努力，圆满地完成了预定的科学目标，取得了下列研究成果（1）冠状动脉粥样硬化数据库和易感基因建立了12000例冠状动脉粥样硬化患者以及与病例相匹配的冠状动脉粥样硬化（AS）数据库和资源库，发现NPR-C是汉族冠心病新的易感基因，阐明NPR-C抑制AS病变的分子机制，发现TrkB是是汉族冠心病新的易感基因；（2）心血管重构的动物模型建立了具有斑块高自发性破裂率和高血栓形成率的小鼠模型，建立了1型和2型糖尿病的糖尿病性心肌病的大鼠模型；（3）心血管重构发生新机制在国际上首次发现了心血管重构的一系列新的分子机制吸烟增加腹主动脉瘤发病率的新机制，寒冷增加心血管病事件的新机制，铁调素促进斑块不稳定的新机制，精氨酸酶II表达调控新机制，精氨酸酶1抑制氧化应激的新机制，PARP1促进脂质过氧化的分子机制，AS的免疫调节新机制, 脂联素增加斑块胶原合成的新机制，膜联蛋白A7在内皮自噬中的重要作用，可调控内皮自噬的非编码RNA,血流切应力调节斑块形成的新机制，精神应激促进斑块破裂的分子机制以及Nrf2改善心脏重构的分子机制;（4）心血管重构检测新方法发现了炎症标记物导致AS的新证据，血浆BDNF水平对急性心血管事件的预测作用，斑块应变对易损斑块的预测价值以及血浆Ang-(1–7)水平对急性心肌梗死和糖尿病心肌重构的预测作用；（5）心血管重构干预新靶点首次证明ACE2过表达可减轻斑块早期病变，Ang-(1–7)可减轻斑块早期病变和稳定斑块晚期病变，TRIB3 基因沉默可抑制和稳定AS病变，强力霉素通过抑制MMPs而稳定AS斑块，他汀增加斑块中Treg数量的治疗新机制，过继转移Treg可稳定易损斑块，ACE2基因过表达可改善心肌梗死和糖尿病性心肌病的左室重构，ACE2基因过表达可改善糖尿病肾脏病变以及TRIB3基因干扰可改善2型糖尿病心肌病的左室重构。
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期刊论文
Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses t
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehy
Phosphatidylcholine-specific phospholipase C /heat shock protein 70 (Hsp70) / transcription factor B
A chemical small molecule induces mouse embryonic stem cell differentiation into functional vascular
Feasibility and safety of transthoracic echocardiography-guided transcatheter closure of atrial sept
Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation o
Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosi
Poly (ADP-ribose) transferase/polymerase-1-deficient mice resistant to age-dependent decrease in &be
Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intr
Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic apoE2/2/LDL receptor2
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tis
"Triple therapy" rather than "Triple threat": a meta-analysis of the two antithrombotic regimens aft
Association of the angiotensin Type 1 receptor gene a1166c polymorphisms with myocardial infarction:
Clopidogrel 150 mg/day versus 75 mg/day in patients undergoing percutaneous coronary intervention: a
Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced ca
Intravascular ultrasound area strain imaging used to characterize tissue components and assess vulne
Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular smooth musc
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mi
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contr
High-dose dexamethasone shifts the balance of stimulatory and inhibitory fcgamma receptors on monocy
JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging Trk
Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipopr
Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-
Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory c
Pathway of Toll-like receptor 7/B cell activating factor/B cell activating factor receptor plays a r
Decreased IDO activity and increased TTS expression break immune tolerance in patients with immune t
Association of plasma brain-derived neurotrophic factor and cardiovascular risk factors and prognosi
Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smoo
Sorting protein-related receptor SorLA controls regulated secretion of Glial cell Line-derived neuro
Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic a
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and r
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and mediates brain-derived n
Phosphorylation of cofilin regulates extinction of conditioned aversive memory via AMPAR trafficking
Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque sta
Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contri
Usefulness of Angiotensin-(1-7) to predict myocardial salvage after percutaneous coronary interventi
Cholinergic neuron-like cells derived From bone marrow stromal cells induced by tricyclodecane-9-yl-
Safrole-2', 3'-oxide induces atherosclerotic plaque vulnerability in apolipoprotein E-knockout mice.
Arginase I Enhances Atherosclerotic Plaque Stabilization by Inhibiting Inflammation and Promoting Sm
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张运
在国际上较早并在国内首先开展了超声心动图负荷试验、多普勒超声心动图、心导管-多普勒同步血流动力学检查、多平面经食管超声心动图、动态和实时三维超声心动图、经静脉心肌声学造影等多项新技术。
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