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生物医用高分子材料
  • 项目名称：生物医用高分子材料
  • 项目类别：国家杰出青年科学基金
  • 批准号：50425311
  • 申请代码：E0310
  • 项目来源：国家自然科学基金
  • 研究期限：2005-01-01-2008-12-31
  • 项目负责人：高长有
  • 负责人职称：教授
  • 依托单位：浙江大学
  • 批准年度：2004
中文摘要：

主要工作为生物医用高分子材料的表面与界面、组织工程和中空微胶囊。首次观察到微胶囊去核过程中的膨胀－收缩现象，测定了聚电介质纳米薄膜的弹性模量；首次发现物质在微胶囊中的自沉积现象和浓度依赖性释放；较早制备与研究了热、离子强度和pH响应的智能微胶囊；最早建立了胺解及生物大分子固定化技术制备高度相容性的细胞支架。99年以来，发表影响因子3以上的系列论文15篇，包括Angew Chem、Adv Mater、Tissue Eng和Biomater等；

中文主题词： 胶体微粒;荧光量子点;特
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 94
  • 70
  • 0
  • 2
  • 2
期刊论文
聚合物纳米粒子的结构和性能对胞吞和细胞功能的影响
Poly(lactic acid) scaffold fabricated by gelatin particle leaching has good biocompatibility for cho
Fabrication and physical and biological properties of fibrin gel derived from human plasma
Fabrication of bovine serum albumin microcapsules by desolvation and destroyable crosslinking
Surface modification and property analysis of biomedical polymers used for tissue engineering
Chitosan–hyaluronic acid hybrid film as a novel wound dressing: in vitro and in vivo studies
Specially elaborated thermally induced phase separation to fabricate poly(L-lactic acid) scaffolds w
软骨细胞在聚乳酸支架中的体外生长行为
Surface wettability of compressed polyelectrolyte multilayers
Preparation and properties of an injectable scaffold of poly(lactic-co-glycolic acid) microparticles
层层组装微胶囊的制备及其智能响应与物质包埋释放性能
Loading and release behaviors of compressed polyelectrolyte multilayers for small dye molecules
Enhanced Angiogenesis in Porous Collagen-Chitosan Scaffolds Loaded with Angiogenin
Microscale control over collagen gradient on poly(L-lactide) membrane surface for manipulating chond
Photoinitiating polymerization to prepare biocompatible chitosan hydrogels
In vitro and in vivo biological performance of collagen-chitosan/silicone membrane bilayer dermal eq
Collagen-coated polylactide microspheres as chondrocyte microcarriers
Collagen/chitosan-silicone membrane bilayer scaffold as a dermal equivalent
Preparation of porous polylactide microspheres by emulsion-solvent evaporation based on solution ind
Collagen-coated polylactide microcarriers/chitosan hydrogel composite: Injectable scaffold for carti
Layer-by-layer assembly of biomacromolecules on poly(ethylene terephthalate) films and fiber fabrics
Fabrication of Thermoresponsive Polymer Gradients for Study of Cell Adhesion and Detachment
壳聚糖涂层聚乳酸细胞微载体的制备和性能
聚(二甘氨酸乙酯)磷腈的合成及其生物相容性
Hydrogel-filled polylactide porous scaffolds for cartilage tissue engineering
N,N,N-trimethyl chitosan chloride as a gene vector: synthesis and application
In vitro and in vivo degradability and cytocompatibility of poly(L-lactic acid) scaffold fabricated
Hollow chitosan-alginate multilayer microcapsules as drug delivery vehicle: doxorubicin loading and
Layer-by-layer assembly of chondroitin sulfate and collagen on aminolyzed poly(l-lactic acid) porous
Crosslinked polysaccharide nanocapsules: Preparation and drug release properties
Multilayer Microcapsules as Anti-Cancer Drug Delivery Vehicle: Deposition, Sustained Release, and in
Ibuprofen-loaded nanoparticles prepared by a co-precipitation method and their release properties
Bioactive Thin Film of Acidic Fibroblast Growth Factor Fabricated by Layer-by-Layer Assembly
Printing biomacromolecules on a bovine serum albumin precursor layer
Microstructure and mechanical properties of poly(L-lactide) scaffolds fabricated by gelatin particle
交联聚乳酸中空微球的制备与表征
Charge-Controlled Permeability of Polyelectrolyte Microcapsules.
Thermosensitive poly(allylamine)-g-poly(N-isopropylacrylamide): synthesis, phase separation and part
Surface modification of poly(ethylene terephthalate) via hydrolysis and layer-by-layer assembly of c
胶原/壳聚糖组织再生支架及其在修复皮肤损伤中的应用
Manipulating the Properties of Polyelectrolyte Microcapsules by Glutaraldehyde Cross-Linking,
Chitosan modified poly(l-lactide) microspheres as cell Microcarriers for cartilage tissue engineerin
Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast gr
The gene transfection efficiency of thermoresponsive N,N,N-trimethyl chitosan chloride-g-poly(N-isop
Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineer
Poly(ethylene glycol) micro-patterns as environmentally sensitive template for selective or non-sele
通过可控沉积和交联制备蛋白质微胶囊
纳米金掺杂中空微胶囊的制备与表征
Progress in fabricating arrays of soft spherical vessels on mesoscale with spatial control
溶剂辅助聚合物微成型
Solvent-assisted polymer micro-molding
交联壳聚糖水凝胶填充层状微胶囊的制备与性能
胶原-磺化羧甲基壳聚糖/硅橡胶皮肤再生材料的制备及其对小型猪烫伤创面全层皮肤缺损的修复研究
会议论文
Controlled Surface Reaction to Obtain Collagen Gradient for Manipulating Cell Distribution
层层自组装生物相容性聚电解质微胶囊
胶原/壳聚糖－硅橡胶双层皮肤支架的研究
具有良好抗细胞收缩能力的胶原基组织工程皮肤支架构建
pH-responsive Protein Microcapsules Fabricated by Covalent Layer-by-layer Assembly
Preparation and Chitosan Nanoparticles and Their Adherence on Hydroxyapatite Surface
明胶致孔剂制备细胞相容性聚乳酸软骨再生支架
聚乳酸膜表面胶原的梯度固定及对细胞粘附性能影响的研究
温敏聚合物膜的制备及其表面形貌研究.
基于壳聚糖的基因传递体系及其细胞吞噬研究
Compression of polyelectrolyte multilayer thin films by a rubber stamp
以共价键作用在化学图案化表面上构建微胶囊阵列
温敏聚合物表面的梯度制备及对细胞行为的影响
可注射型PLGA纳米粒子/壳聚糖水凝胶复合支架
注射型纤维蛋白凝胶支架的制备及其对成纤维细胞生长的促进作用
壳聚糖基双层敷料的制备及其功能化
Polymer scaffolds for skin and cartilage tissue engineering
Facile technologies for fabricating bioactive scaffolds
Facile pathways for fabricating cell-compatible scaffolds
Scaffolding materials for tissue regeneration
聚烯丙基胺接枝聚N-异丙基丙烯酰胺共聚物微粒的制备及其温敏性能研究
Biomedical Materials: From Basic Science to Potential Applications
Cytocompatible and cytoinductive biomaterials and scaffolds for tissue engineering and regenerative
A Simple Method for the Stabilization and Surface Functionalization of PLGA Nanoparticles
Scaffolding materials with controlled surface properties and inductive regeneration of dermis
Cytocompatible and cytoinductive biomaterials and scaffolds for tissue engineering and regenerative
Fabrication of Thermoresponsive and Ligand-enhanced Non-viral Gene Vectors and Applications in Angio
Collagen gradient created on poly(L-lactide) surface to manipulate chondrocyte distribution
Surface Modification of Biomedical Polymers for Manipulating Cell Attachment and Growth
Manipulating the structure and properties of multilayer microcapsules
Hydrogel-filled polylactide porous scaffolds for cartilage tissue engineering
生物相容性聚合物支架的制备与应用
高分子溶剂辅助微成型
Incorporating TMC/DNA complexes into a porous collagen scaffold to enhance angiogenesis
基于主客体相互作用制备微胶囊及其性能研究
纳米微囊药物与自沉积过程
Covalently crosslinked chitosan hydrogel formed at neutral pH and body temperature
Fabrication and biomedical applications of biocompatible polymer scaffolds
A novel collagen/chitosan-silicon membrane bilayer scaffold as a dermal equivalent: in vitro and in
Composite porous scaffolds fabricated by hydrogel filling for cartilage regeneration
Multilayer nanofilms and microcapsules for biomedical applications
Biocompatible scaffolds for tissue engineering and regenerative medicine
聚乳酸表面光接枝后的层层自组装改性.
载药PLGA纳米粒子的制备及释放性能的研究
水凝胶负载化软骨组织工程用支架
生物降解聚多糖纳米胶囊制备与性能
纳米微囊药物与自沉积过程
用于组织修复和再生的高分子材料的研究与应用
胶体微粒与细胞吞噬－从科学规律探索到潜在应用
戊二醛交联调控层状组装微胶囊的性能
Permeability control of multilayer microcapsules by charge interaction
Layer-by-layer self-assembly of biomacromolecules to build an analogue to extracellular matrix
Growth factor thin film fabricated by layer-by-layer assembly
Biomimetic hydrogel/porous scaffold composite for cartilage regeneration.
Cell-mediated contraction of collagen based scaffold for skin tissue engineering: phenomenon and str
Layer-by-layer assembly to modify poly(ethylene terephthlate)?fiber fabrics toward promoting its end
Fabrication, Structures and properties of microcapsules by in situ polyelectrolyte coacervation on d
Hydrogel filling: composite of “hard” and “soft” scaffolds for cartilage tissue engineering
Practical pathways to cytocompatible and cytoinductive polymers and 3D scaffolds
PLGA nanoparticles for protein delivery: preparation and protein-loading behavior
Electrospinning of loosely constructed tissue scaffold
Microscale Control of RGD gradient on PLLA Membrane Surface to Manipulate Cell Response.
Smart microcapsules with layered structure: from basic chemistry to potential applications
Chitosan based gene delivery system and particle internalization
Microcapsules for drug delivery: from basic chemistry to potential applications.
层状组装微胶囊的制备及应用
高分子科学与再生医学
胶体微粒的制备及其胞吞性能研究
组织再生用高分子材料的研究与应用
层层自组装超薄膜的压缩：现象、机理及应用
获奖
超分子层状组装微胶囊的制备、性能与功能化研究
超分子层状组装微胶囊的制备、性能与功能化研究
著作
《医用高分子材料》
《中国材料工程大典》第10卷《复合材料工程》第16篇，第4章“光功能复合材料”
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