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智能微胶囊的制备、特异识别与填充释放
  • 项目名称：智能微胶囊的制备、特异识别与填充释放
  • 项目类别：重点项目
  • 批准号：20434030
  • 申请代码：B040303
  • 项目来源：国家自然科学基金
  • 研究期限：2005-01-01-2008-12-31
  • 项目负责人：高长有
  • 负责人职称：教授
  • 依托单位：浙江大学
  • 批准年度：2004
中文摘要：

研究模板组装与模板聚合法制备聚合物中空微胶囊技术。通过弱相互作用体系组装或聚合得到pH、温度、离子强度调控开关特性与收缩－膨胀特性的智能微胶囊，研究其微结构变化；研究微胶囊的表面特异修饰技术，实现微胶囊与模型表面的特异识别。利用自沉积技术和环境调控开关特性将药物选择性、高效包埋到微胶囊内，阐明药物的释放动力学与释放机理。通过体内外细胞培养与动物实验，检测微囊化药物诱导肿瘤细胞凋亡的效果。本项目将建立智能微胶囊的新制备技术与药物包埋、释放的新方法与新机制。在基础研究层面上，可以揭示微胶囊的智能响应特性与微结构的关系，阐明发生变化的内在机制与机理，进而促进新物质与新材料的设计和开发；在应用层面上，能够为药物的包埋、传递与释放提供一种新的载体材料，为疾病的治疗提供一种新方案。

中文主题词： 微胶囊;胶体;智能;特异识别;自沉积
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 73
  • 35
  • 0
  • 2
  • 1
期刊论文
肝细胞微囊化技术理论进展与临床应用
自组装阿霉素微囊肝动脉灌注对兔VX2肿瘤细胞代谢及凋亡的影响
Polyphosphazene Microcapsules Fabricated through Covalent Assembly
层层组装微胶囊的制备及其智能响应与物质包埋释放性能
交联壳聚糖水凝胶填充层状组装微胶囊的制备与性能
通过可控沉积和交联制备蛋白质微胶囊
纳米金掺杂中空微胶囊的制备与表征
Progress in fabricating arrays of soft spherical vessels on mesoscale with spatial control
Multilayer microcapsules with tailored structures for bio-related applications
Multilayer poly(ethyleneimine) microcapsules: glutaraldehyde mediated assembly and the influence of
pH-responsive protein microcapsules fabricated via glutaraldehyde mediated covalent layer-by-layer a
Manipulating the properties of coacervated polyelectrolyte microcapsules by chemical crosslinking
原位凝聚法制备聚电解质微胶囊：模板中聚电解质掺杂量对微胶囊结构与性能的影响
Polyelectrolyte coated PLGA nanoparticles: templation and release behavior
Biomimetic modification of chitosan with covalently grafted lactose and blended heparin for improvem
Stepwise interfacial self-assembly of nanoparticles via specific DNA pairing,
Chitosan Nanoparticles for Loading of Toothpaste Actives and Adhesion on Tooth Analogs
Gelatin/chitosan/hyaluronan ternary complex scaffold containing basic fibroblast growth factor for c
The influence of polycaprolactone coating on the internalization and cytotoxicity of gold nanopartic
Incorporation of Basic Fibroblast Growth Factor by a Layer-by-Layer Assembly Technique to Produce Bi
Rings of Hydrogel Fabricated by a Micro-Transfer Technique
Selective removal of particle cores to fabricate manganese carbonate hollow spheres and composite mi
Layered microcapsules for daunorubicin loading and release as well as in vitro and in vivo studies
Covalently crosslinked chitosan hydrogel formed at neutral pH and body temperature
Assembly of multilayer microcapsules on CaCO3 particles from biocompatible polysaccharides
Equilibrium Distribution of Permeants in Polyelectrolyte Microcapsules Filled with Negatively Charge
Influence of assembling pH on the stability of poly(L-glutamic acid) and poly(L-lysine) multilayers
Assembly of polymeric micelles into hollow microcapsules with extraordinary stability against extrem
Stepwise assembly of the same polyelectrolytes using host-guest interaction to obtain microcapsules
Influence of Drying Time of Polyelectrolyte Multilayers on the Compression-Induced Pattern Formation
Preparation and properties of ionically cross-linked chitosan nanoparticles
Direct Covalent Assembly to Fabricate Microcapsules with Ultrathin Walls and High Mechanical Strengt
Template Polymerization to Fabricate Hydrogen-Bonded Poly(acrylic acid)/Poly(vinylpyrrolidone) Hollo
Hollow microcapsules with a complex polyelectrolyte shell structure fabricated by polymerization of
A facile pathway to fabricate microcapsules by in situ polyelectrolyte coacervation on poly(styrene
Polyelectrolyte microcapsules templated on poly(styrene sulfonate)-doped CaCO3 particles for loading
Thermosensitive poly(allylamine)-g-poly(N-isopropylacrylamide) copolymers: Salt-tuned phase separati
In situ coacervated microcapsules with filled polyelectrolytes and charge-controlled permeation for
Chitosan-Mediated Synthesis of Gold Nanoparticles on Patterned Poly(dimethylsiloxane) Surfaces
Compression-Inhibited Pore Formation of Polyelectrolyte Multilayers Containing Weak Polyanions: A Sc
Biologically Driven Assembly of Polyelectrolyte Microcapsule Patterns To Fabricate Microreactor Arra
Polylactide hollow spheres fabricated by interfacial polymerization in an oil-in-water emulsion syst
Stable weak polyelectrolyte microcapsules with pH-responsive permeability
Fabrication of microcapsule arrays on chemically patterned surfaces via covalent linking
海藻酸钠/壳聚糖微囊冻存的低温显微实验
自组装阿霉素微囊对兔肝脏VX2移植瘤治疗的PET/CT评价
Single Polyelectrolyte Microcapsules Fabricated By Glutaraldehyde-Mediated Covalent Layer-By-Layer A
Two-dimensional chemically tunable patterns with cellular structures fabricated via thermal pressing
Stable microcapsules assembled stepwise from weak polyelectrolytes followed by thermal crosslinking
Robust poly(allylamine)-graft-poly(Nisopropylacrylamide) particles prepared by physical crosslinking
Multilayer Capsules with Cell-like Topology: Fabrication and Spontaneous Loading of Various Substanc
Preformed microcapsules for loading and sustained release of ciprofloxacin hydrochloride
微囊化细胞的低温保存
交联壳聚糖水凝胶填充层状微胶囊的制备与性能
Preliminary Characteristic of Alginate, Heparin-Chitosan-Alginate, Heparin Microencapsulated Hepatocytes System
会议论文
高分子科学与再生医学
层层自组装超薄膜的压缩：现象、机理及应用
戊二醛交联调控层状组装微胶囊的性能
pH-responsive Protein Microcapsules Fabricated by Covalent Layer-by-layer Assembly
Preparation and Chitosan Nanoparticles and Their Adherence on Hydroxyapatite Surface
层层自组装生物相容性聚电解质微胶囊
Fabrication and biomedical applications of biocompatible polymer scaffolds
Multilayer nanofilms and microcapsules for biomedical applications
Smart microcapsules with layered structure: from basic chemistry to potential applications
Chitosan based gene delivery system and particle internalization
高分子溶剂辅助微成型
Growth factor thin film fabricated by layer-by-layer assembly
Compression of polyelectrolyte multilayer thin films by a rubber stamp
以共价键作用在化学图案化表面上构建微胶囊阵列
基于主客体相互作用制备微胶囊及其性能研究
纳米微囊药物与自沉积过程
生物降解聚多糖纳米胶囊制备与性能
Practical pathways to cytocompatible and cytoinductive polymers and 3D scaffolds
聚烯丙基胺接枝聚N-异丙基丙烯酰胺共聚物微粒的制备及其温敏性能研究
层状组装微胶囊的制备及应用
Electrospinning of loosely constructed tissue scaffold
Microscale Control of RGD gradient on PLLA Membrane Surface to Manipulate Cell Response.
Scaffolding materials for tissue regeneration
Facile technologies for fabricating bioactive scaffolds
Facile pathways for fabricating cell-compatible scaffolds
Hydrogel filling: composite of “hard” and “soft” scaffolds for cartilage tissue engineering
Covalently crosslinked chitosan hydrogel formed at neutral pH and body temperature
Manipulating the structure and properties of multilayer microcapsules
Microcapsules for drug delivery: from basic chemistry to potential applications.
A novel collagen/chitosan-silicon membrane bilayer scaffold as a dermal equivalent: in vitro and in
胶体微粒与细胞吞噬－从科学规律探索到潜在应用
Permeability control of multilayer microcapsules by charge interaction
Biomimetic hydrogel/porous scaffold composite for cartilage regeneration.
Fabrication, Structures and properties of microcapsules by in situ polyelectrolyte coacervation on d
Layer-by-layer assembly to modify poly(ethylene terephthlate)?fiber fabrics toward promoting its end
获奖
超分子层状组装微胶囊的制备、性能与功能化研究
超分子层状组装微胶囊的制备、性能与功能化研究
著作
《医用高分子材料》
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