欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
该项目按原计划完成。我们从系统生物学的角度，基于SNP突变谱、miRNA和靶基因（mRNA）双重表达谱等高通量数据，研究了miRNA作用靶基因识别与再确认、miRNA-mRNA双重表达谱分析新方法和新技术。建立与完善了miRNA相关数据库，结合功能进行miRNA靶点预测方法的研究；研究了19种癌症microRNA层面上癌症的公共机制；研究microRNA与microRNA的协同网络及对复杂疾病的影响；优化疾病风险microRNA；在SubpathwayMiner平台开发的基础上，建立了疾病与microRNA、microRNA与Subpathway间的关系网络，从而分析疾病相关microRNA的拓扑性质。发表论文40篇（SCI 36篇；国际国内会议论文2篇，其它2篇），研究论文发表在国外著名生命科学杂志《Briefings in Bioinformatics》、《Nucleic Acids Research》、《Bioinformatics》、《BMC System Biology》，《Gene》等杂志，同时研究成果也进行国内国际交流和实际应用。
结论摘要：
英文主题词complex diseases; association; miRNA-mRNA coordination; functional modules
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Human Protein Structural Interaction Network: Domain Effects on Network Topology and Protein Functio
MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA
Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exp
The application of gene co-expression network reconstruction based on CNVs and gene expression micro
Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target-Dysregulated Netwo
Identifying highly conserved and highly differentiated gene ontology categories in human populations
Topological properties of the drug targets regulated by microRNA in human protein-protein interactio
The analysis of the drug-targets based on the topological properties in the human protein-protein in
In silico detection and characteristics of novel microRNA genes in the Equus caballus genome using a
Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge fra
Differential expression pattern-based prioritization of candidate genes through integrating disease-
相关项目
李霞的项目