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中文摘要：
阿尔茨海默症(Alzheimer's Disease，AD)是老年痴呆的一种最常见形式，已成为继肿瘤、心脏病和中风之后，严重威胁老年人身心健康的主要疾病之一，而AD只能通过病人死后尸检脑内的Aβ斑块来确诊。目前，我国正在快速步入老龄化社会，AD的防治工作任务艰巨，研究AD的早期诊断方法具有极其重要的意义。因此，本课题将以脑内Aβ斑块为靶点，设计并制备一系列具有推-拉电子结构的近红外荧光探针，通过荧光染色实验、体外竞争结合实验、正常小鼠体内分布实验、AD转基因小鼠活体荧光显像实验等多种方法对它们进行全面的生物学评价，筛选出与Aβ斑块具有高亲和性和选择性的近红外Aβ斑块荧光分子探针，通过光学成像的方法实现早期、无创伤的准确诊断AD。同时，这些荧光探针可以方便地进行11C或18F标记，开发成用于PET显像的Aβ斑块显像剂。
结论摘要：
英文主题词Alzheimer's disease；Aβ plaque；near-infrared；imaging probe；
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期刊论文
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Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-beta Plaques in Alzheim
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