位置：立项数据库 > 立项详情页
内分泌代谢性疾病
  • 项目名称：内分泌代谢性疾病
  • 项目类别：优秀青年科学基金项目
  • 批准号：81222008
  • 申请代码：H0711
  • 项目来源：国家自然科学基金
  • 研究期限：2013-01-01-2015-12-31
  • 项目负责人：毕宇芳
  • 负责人职称：副主任医师
  • 依托单位：上海交通大学
  • 批准年度：2012
中文摘要：

申请者立足临床深入科研，带领团队建立以“城镇化进程中代谢性疾病风险研究”、“中国糖尿病调查”、“REACTION Study（Risk Evaluation of Cancers in Diabetic Individuals）”三项研究为基础的全国人群研究基地，创建40万人份信息与样本资源库，致力研究2型糖尿病等代谢性疾病的环境与遗传危险因素。其中“环境内分泌干扰物双酚A高暴露增加代谢异常风险”研究结论，为双酚A是否影响代谢的争议提供依据，结果发表于JCEM、Kidney Int、Ann Intern Med等高影响力期刊。发表SCI收录论著29篇，第一和/或通讯作者12篇，他引174次。本项目将在既往研究基础上，通过人群随访进一步证实双酚A长期高暴露导致代谢异常，并基于动物模型深入研究双酚A影响代谢的分子机制。研究可望探索更合理的通过改善环境降低2型糖尿病等代谢性疾病风险的防治新模式。

中文主题词： 2型糖尿病；代谢性疾病；危险因素；环境内分泌干扰物；双酚A
结论摘要：

英文主题词Type 2 Diabetes；Metabolic Disorders；Risk Factors；EEDs；Bisphenol A

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 36
  • 0
  • 0
  • 0
  • 0
期刊论文
Prevalence and Control of Diabetes in Chinese Adults
Advanced research on risk factors of type 2 diabetes.
Impaired Lung Function Is Associated with Increased Carotid Intima-Media Thickness in Middle-Aged an
Autonomic Test by EZSCAN in the Screening for Prediabetes and Diabetes
Active Smoking, Passive Smoking, and Risk of Nonalcoholic Fatty Liver Disease (NAFLD): A Population-
Significant Coronary Stenosis in Asymptomatic Chinese With Different Glycemic Status.
Serum potassium level is associated with metabolic syndrome: A population-based study
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.
Diabetes genetic risk score modifies effect of bisphenol A exposure on deterioration in glucose meta
Serum total bilirubin levels and prevalence of diabetic retinopathy in a Chinese population
Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosis.
Low Serum Magnesium Level Is Associated with Microalbuminuria in Chinese Diabetic Patients.
Urinary Bisphenol A Concentration and Thyroid Function in Chinese Adults
Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION
Prevalence and Control of Diabetes in Chinese Adults.
Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabo
Low-grade albuminuria is associated with peripheral artery disease in Chinese diabetic patients.
Status ofCardiovascular Health in Chinese Adults.
Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Ad
Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly
Associations of smoking and alcohol consumption with impaired beta-cell function in Chinese men.
Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease.
Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin res
Association between history of abortion and nonalcoholic fatty liver disease in middle-aged and elde
Circulating Prolactin Associates With Diabetes and Impaired Glucose Regulation A population-based st
The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese populati
北京地区中老年人群脑卒中及其危险因素现况调查
Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese
Association of Bisphenol A Exposure with Circulating Sex Hormone Concentrations in Men and Postmenopausal Women
Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese
相关项目
双酚A胚胎期暴露对胰岛β细胞发育的影响及与成年后糖代谢异常的关系
期刊论文 4
高效双酚A降解菌的降解机理研究
期刊论文 6
2型糖尿病遗传家系易感基因及危险因素研究
期刊论文 12 会议论文 2
食品中环境内分泌干扰物的电化学生物传感快速检测技术
期刊论文 4
双酚A对成年神经行为和突触可塑性的影响及其机制研究
期刊论文 20
双酚A对发育中脑内NMDA受体的影响及其机制研究
期刊论文 17
蒙古族2型糖尿病的样本收集与致病基因研究
期刊论文 8
赣南地区T2DM易感基因、环境危险因素及其交互作用的研究
期刊论文 7
从糖尿病心脑损害发生过程探讨病络理论的病生理学基础
期刊论文 6 会议论文 3
毕宇芳的项目
环境内分泌干扰物双酚A致代谢紊乱的作用机制研究
ACTH依赖性库欣综合征的糖皮质激素抵抗机制及干预治疗
期刊论文 4
运动干预在中澳糖尿病前期和新发糖尿病中对代谢表型组的影响
期刊论文 3